4-Bromo-2-hydrazinylpyridine

Base Information

• Chemical Name: 4-Bromo-2-hydrazinylpyridine
• CAS No.: 1019918-39-8
• Molecular Formula: C5H6BrN3
• Molecular Weight: 186.97
• Hs Code.: 2933990090
• European Community (EC) Number: 869-728-1
• DSSTox Substance ID: DTXSID10695067
• Wikidata: Q82624071
• Mol file: 1019918-39-8.mol

Synonyms:4-Bromo-2-hydrazinylpyridine;1019918-39-8;(4-bromopyridin-2-yl)hydrazine;4-Bromo-2-hydrazinopyridine;MFCD00234091;1-(4-BROMOPYRIDIN-2-YL)HYDRAZINE;(4-Bromo-pyridin-2-yl)-hydrazine;SCHEMBL379728;SCHEMBL20602766;SCHEMBL20985956;DTXSID10695067;JNOVZPGBPRDTHN-UHFFFAOYSA-N;Pyridine, 4-bromo-2-hydrazinyl-;AMY36365;1-(4-bromopyridin-2-yl) hydrazine;AKOS006273635;SB53078;AS-43214;SY043156;CS-0067914;EN300-94254;A896982

Chemical Property of 4-Bromo-2-hydrazinylpyridine

Chemical Property:

• PSA: 50.94000
• LogP: 1.90300
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 186.97451
• Heavy Atom Count: 9
• Complexity: 88.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-2-hydrazinylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C=C1Br)NN

Technology Process of 4-Bromo-2-hydrazinylpyridine

There total 1 articles about 4-Bromo-2-hydrazinylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-bromo-2-fluoropyridine (128071-98-7) → 4-bromo-2-hydrazineylpyridine (1019918-39-8)

Guidance literature:

With hydrazine hydrate; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 16h;

Reference yield: 90.0%

formic acid (64-18-6) + 4-bromo-2-hydrazineylpyridine (1019918-39-8) → 7-bromo-[1,2,4]triazolo[4,3-a]pyridine (832735-60-1)

Guidance literature:

at 100 ℃;

Reference yield: 71.0%

4-bromo-2-hydrazineylpyridine (1019918-39-8) + 4-methoxyphenyl-acetic chloride (4693-91-8) → N'-(4-bromopyridin-2-yl)-2-(4-methoxyphenyl)acetohydrazide

Guidance literature:

In acetonitrile; Reflux; Inert atmosphere;

upstream raw materials:

4-bromo-2-fluoropyridine

Downstream raw materials:

1-(4-bromopyridin-2-yl)-4-isopropylsemicarbazide

7-Bromo-3-(2-chlorophenyl)-[1,2,4]triazolo[4,3-a]pyridine

7-bromo-[1,2,4]triazolo[4,3-a]pyridine

7-bromo-3-methyl-[1,2,4]triazolo[4,3-a]pyridine

Refernces

• 1、 -. "GPR52 MODULATOR COMPOUNDS". Page/Page column 75-76. . Retrieved 2021/05/15.
• 2、 -. "SUBSTITUTED OXOPYRIDINE DERIVATIVES". Page/Page column 161-162. . Retrieved 2020/07/14.