Methyl 5-bromo-6-methylpicolinate

Base Information

• Chemical Name: Methyl 5-bromo-6-methylpicolinate
• CAS No.: 1215860-20-0
• Molecular Formula: C8H8BrNO2
• Molecular Weight: 230.05862
• Hs Code.: 2933399090
• Mol file: 1215860-20-0.mol

Synonyms:Methyl 5-bromo-6-methylpicolinate;5-bromo-6-methyl-2-pyridine carboxylic acid methyl ester;

Chemical Property of Methyl 5-bromo-6-methylpicolinate

Chemical Property:

• Boiling Point: 301.8±37.0 °C(Predicted)
• PKA: -0.43±0.10(Predicted)
• PSA: 39.19000
• Density: 1.503±0.06 g/cm3(Predicted)
• LogP: 1.93910
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-Bromo-6-methylpicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5-bromo-6-methylpicolinate

There total 1 articles about Methyl 5-bromo-6-methylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methanol (67-56-1) + 3-bromo-2-methyl-6-pyridinecarboxylic acid (137778-20-2) → 5-bromo-6-methylpyridine-2-carboxylic acid methylester (1215860-20-0)

Guidance literature:

With thionyl chloride; at 20 - 65 ℃; for 2h; Industry scale;

Reference yield: 76.0%

5-bromo-6-methylpyridine-2-carboxylic acid methylester (1215860-20-0) → 5-bromo-6-methyl-pyridine-2-carbaldehyde (137778-18-8)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

Reference yield:

5-bromo-6-methylpyridine-2-carboxylic acid methylester (1215860-20-0) + 4-bromo-Ν-α-[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-N-[4-(2H-tetrazol-5-yl)phenyl]-L-phenylalaninamide + bis(pinacol)diborane (73183-34-3) → 5-{4-[(2S)-2-{[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]amino}-3-oxo-3-{[4-(2H-tetrazol-5-yl)phenyl]amino}propyl]phenyl}-6-methylpyridin-2-carboxylic acid

Guidance literature:

5-bromo-6-methylpyridine-2-carboxylic acid methylester; bis(pinacol)diborane; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In toluene; at 110 ℃; for 3h; Inert atmosphere;

4-bromo-Ν-α-[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-N-[4-(2H-tetrazol-5-yl)phenyl]-L-phenylalaninamide; With sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 20 ℃; for 16h;

upstream raw materials:

methanol

3-bromo-2-methyl-6-pyridinecarboxylic acid

Downstream raw materials:

5-bromo-6-methyl-pyridine-2-carbaldehyde

tert-butyl 4-[[6-methyl-5-(2-methylphenyl)pyridin-2-yl]methyl]piperazine-1-carboxylate

1-[[6-methyl-5-(2-methylphenyl)pyridin-2-yl]methyl]piperazine

1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[6-methyl-5-(2-methylphenyl)pyridin-2-yl]methyl]piperazine-1-carboxylate