1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol mesylate

Base Information

• Chemical Name: 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol mesylate
• CAS No.: 1266685-11-3
• Molecular Formula: CH₄O₃S*C₃₀H₃₄N₂O₃
• Molecular Weight: 566.719
• Mol file: 1266685-11-3.mol

Synonyms:1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol mesylate

Chemical Property of 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol mesylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol mesylate

There total 9 articles about 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonic acid (75-75-2,98527-29-8) + bazedoxifene (198481-32-2) → 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol mesylate (1266685-11-3)

Guidance literature:

With ascorbic acid; In acetone;

Reference yield:

1-{2-[4-(chloromethyl)phenoxy]ethyl}hexahydro-1H-azepine hydrochloride (223251-25-0) → 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol mesylate (1266685-11-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C

1.2: 5 °C

2.1: hydrogen / palladium 10% on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr

3.1: ascorbic acid / acetone

With hydrogen; sodium hydride; ascorbic acid; palladium 10% on activated carbon; In methanol; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

1-(2-chloroethyl)azepane hydrochloride (26487-67-2) → 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol mesylate (1266685-11-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydroxide / tetrabutylammomium bromide / toluene; water / Reflux

2.1: hydrogenchloride / dichloromethane / 25 - 35 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; toluene / -5 - -1 °C

3.2: 5 °C

4.1: hydrogen / palladium 10% on activated carbon / water; acetone; methanol / 40 °C / 7355.72 Torr

5.1: ascorbic acid / acetone

With hydrogenchloride; hydrogen; sodium hydride; sodium hydroxide; ascorbic acid; palladium 10% on activated carbon; tetrabutylammomium bromide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

upstream raw materials:

(4-hydroxyphenyl)methanol

methanesulfonic acid

bazedoxifene

5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-azepan-1-yl-ethoxy)-benzyl]-1H-indole