ABT-348

Base Information

• Chemical Name: ABT-348
• CAS No.: 1227939-82-3
• Molecular Formula: C25H21FN6O2S
• Molecular Weight: 488.545
• Mol file: 1227939-82-3.mol

Synonyms:Ilorasertib;

Chemical Property of ABT-348

Chemical Property:

• PSA: 150.55000
• LogP: 5.20110

Purity/Quality:

97% ^*data from raw suppliers

Ilorasertib ≥98.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ABT-348

There total 19 articles about ABT-348 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethanol (1040377-08-9) + 1-(4-(4-amino-7-iodothieno[3,2-c]pyridin-3-yl)phenyl)-3-(3-fluorophenyl)urea (1420775-77-4) → ABT-348 (1227939-82-3)

Guidance literature:

With palladium diacetate; potassium hydroxide; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In tetrahydrofuran; water; for 2h; Inert atmosphere; Reflux;

Reference yield: 91.0%

2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethanol (1040377-08-9) + 1-(4-(4-amino-7-bromothieno[3,2-c]pyridin-3-yl)phenyl)-3-(3-fluorophenyl)urea → ABT-348 (1227939-82-3)

Guidance literature:

With palladium diacetate; potassium hydroxide; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; Reflux; Inert atmosphere;

Reference yield: 80.0%

2-(4-(4-amino-3-(4-aminophenyl)thieno[3,2-c]pyridin-7-yl)-1H-pyrazol-1-yl)ethanol (1227939-87-8) + 1-fluoro-3-isocyanatobenzene (404-71-7) → ABT-348 (1227939-82-3)

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; at -20 ℃;

DOI:10.1016/j.bmcl.2012.03.035

upstream raw materials:

2-(4-(4-amino-3-(4-aminophenyl)thieno[3,2-c]pyridin-7-yl)-1H-pyrazol-1-yl)ethanol

1-fluoro-3-isocyanatobenzene

3-bromo-4-amino-[3,2-c]-thienopyridine

3-(4-aminophenyl)-7-iodothieno[3,2-c]pyridin-4-amine