2-(2-CHLOROPHENYL)-2-(METHYLAMINO)CYCLOHEXAN-1-ONE

Base Information

• Chemical Name: 2-(2-CHLOROPHENYL)-2-(METHYLAMINO)CYCLOHEXAN-1-ONE
• CAS No.: 100477-72-3
• Molecular Formula: C13H16ClNO
• Molecular Weight: 237.728
• Mol file: 100477-72-3.mol

Synonyms:

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Chemical Property of 2-(2-CHLOROPHENYL)-2-(METHYLAMINO)CYCLOHEXAN-1-ONE

Chemical Property:

• PSA: 29.10000
• LogP: 3.28870

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-CHLOROPHENYL)-2-(METHYLAMINO)CYCLOHEXAN-1-ONE

There total 72 articles about 2-(2-CHLOROPHENYL)-2-(METHYLAMINO)CYCLOHEXAN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(+/-)-ketamine hydrochloride (1867-66-9) → ketamine (6740-88-1,100477-72-3,33643-46-8,33643-49-1)

Guidance literature:

With sodium hydroxide; In chloroform; water;

Reference yield: 90.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + norketamine (35211-10-0,83777-65-5) → ketamine (6740-88-1,100477-72-3,33643-46-8,33643-49-1)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 12h;

Reference yield: 85.3%

(±)-2-(2-chlorophenyl)-2-hydroxycyclohexan-1-one + methylamine (74-89-5) → ketamine (6740-88-1,100477-72-3,33643-46-8,33643-49-1)

Guidance literature:

(±)-2-(2-chlorophenyl)-2-hydroxycyclohexan-1-one; With methanesulfonyl chloride; triethylamine; In tetrahydrofuran; at -5 - 0 ℃; for 1h; Inert atmosphere;

methylamine; In ethanol; at 15 - 20 ℃;

DOI:10.1021/acs.joc.0c01090

upstream raw materials:

DL-N-Nitrosoketamin

(+/-)-ketamine hydrochloride

2-(2-chlorophenyl)-2-nitrocyclohexan-1-one

formaldehyd

Downstream raw materials:

6-(Methylamino)-6-(2-chlorophenyl)cyclohex-2-enone

2-(2-Chlorophenyl)-N-methyl-2-cyclopentene-1-carboxamide

5-(2-Chlorophenyl)-6-methyl-6-azabicyclo<3.2.0>heptan-7-one

2-(Methylamino)-2-(2-chlorophenyl)cyclopentanemethanol hydrochloride