Methyl 6-hydroxy-5-iodonicotinate

Base Information

Chemical Name:Methyl 6-hydroxy-5-iodonicotinate
CAS No.:885950-46-9
Molecular Formula:C7H6INO3
Molecular Weight:279.034
Hs Code.:2933399090
DSSTox Substance ID:DTXSID00594696
Wikidata:Q82489603
Mol file:885950-46-9.mol

Synonyms:METHYL 6-HYDROXY-5-IODONICOTINATE;885950-46-9;Methyl 5-iodo-6-oxo-1,6-dihydro-3-pyridinecarboxylate;methyl 5-iodo-6-oxo-1H-pyridine-3-carboxylate;5-Iodo-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester;Methyl 1,6-dihydro-5-iodo-6-oxopyridine-3-carboxylate;methyl 5-iodo-6-oxo-1,6-dihydropyridine-3-carboxylate;Methyl 1,6-dihydro-5-iodo-6-oxonicotinate;6-Hydroxy-5-iodo-nicotinic acid methyl ester;SCHEMBL544803;DTXSID00594696;LHGAGXUKDZFFSF-UHFFFAOYSA-N;MFCD08276965;AKOS005069360;AKOS027339039;AS-8544;DA-32299;CS-0081055;EN300-7359036;10Z-0704;METHYL 6-HYDROXY-5-IODOPYRIDINE-3-CARBOXYLATE;Z1269115281

Suppliers and Price of Methyl 6-hydroxy-5-iodonicotinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl6-Hydroxy-5-iodonicotinate
50mg
$ 60.00

SynQuest Laboratories
Methyl 6-hydroxy-5-iodonicotinate
5 g
$ 333.00

SynQuest Laboratories
Methyl 6-hydroxy-5-iodonicotinate
250 mg
$ 52.00

SynQuest Laboratories
Methyl 6-hydroxy-5-iodonicotinate
1 g
$ 120.00

Matrix Scientific
Methyl 5-iodo-6-oxo-1,6-dihydro-3-pyridinecarboxylate >95%
500mg
$ 94.00

Matrix Scientific
Methyl 5-iodo-6-oxo-1,6-dihydro-3-pyridinecarboxylate >95%
1g
$ 144.00

Matrix Scientific
Methyl 5-iodo-6-oxo-1,6-dihydro-3-pyridinecarboxylate >95%
5g
$ 508.00

Matrix Scientific
Methyl 6-hydroxy-5-iodonicotinate
1g
$ 250.00

Crysdot
Methyl6-hydroxy-5-iodonicotinate 97%
1g
$ 145.00

Crysdot
Methyl6-hydroxy-5-iodonicotinate 97%
5g
$ 430.00

Total 8 raw suppliers

Chemical Property of Methyl 6-hydroxy-5-iodonicotinate

Chemical Property:

Melting Point:209～211℃
PSA：59.16000
LogP:0.76610
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:278.93924
Heavy Atom Count:12
Complexity:293

Purity/Quality:

99%, ^*data from raw suppliers

Methyl6-Hydroxy-5-iodonicotinate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CNC(=O)C(=C1)I

Technology Process of Methyl 6-hydroxy-5-iodonicotinate

There total 3 articles about Methyl 6-hydroxy-5-iodonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 66171-50-4
methyl 6-hydroxynicotinate

: 885950-46-9
6-hydroxy-5-iodonicotinic acid methyl ester

Guidance literature:: With N-iodo-succinimide; In N,N-dimethyl-formamide; at 70 ℃; for 3h;

Reference yield: 28.6%

: 67-56-1
methanol

: 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid

: 885950-46-9
6-hydroxy-5-iodonicotinic acid methyl ester

Guidance literature:: With N-iodo-succinimide; sulfuric acid; at 60 ℃; for 4h;

Reference yield:

: 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid

: 885950-46-9
6-hydroxy-5-iodonicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / 72 h / Heating

2: N-iodosuccinimide / methanol / 1 h / 50 °C

With hydrogenchloride; N-iodo-succinimide; In methanol;
DOI:10.1021/jm0602413