methyl morpholine-2-carboxylate hydrochloride

Base Information

• Chemical Name: methyl morpholine-2-carboxylate hydrochloride
• CAS No.: 937063-34-8
• Molecular Formula: C6H12ClNO3
• Molecular Weight: 181.619
• Hs Code.: 2934999090
• Mol file: 937063-34-8.mol

Synonyms:methyl morpholine-2-carboxylate hydrochloride;2-Morpholinecarboxylic acid methyl ester hydrochloride (1:1);2-Morpholinecarboxylic acid methyl ester HCl

Chemical Property of methyl morpholine-2-carboxylate hydrochloride

Chemical Property:

• PSA: 47.56000
• LogP: 0.27860
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

MethylMorpholine-2-carboxylateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl Morpholine-2-carboxylate Hydrochloride is used as a preparation of chromen-4-one derivative for the treatment of hepatitis B virus infection.

Technology Process of methyl morpholine-2-carboxylate hydrochloride

There total 3 articles about methyl morpholine-2-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(t-butyloxycarbonyl)morpholine-2-carboxylic acid methyl ester (500789-41-3) → methyl 2-morpholine carboxylate hydrochloride (937063-34-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 15h;

DOI:10.1016/j.bmc.2012.02.054

Reference yield: 46.0%

methanol (67-56-1) + 2-carboxymorpholine acid (300582-83-6,154731-81-4) → methyl 2-morpholine carboxylate hydrochloride (937063-34-8)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 5h; Reflux;

Reference yield:

4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid (189321-66-2) → methyl 2-morpholine carboxylate hydrochloride (937063-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 15 h / 20 °C

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.02.054

upstream raw materials:

4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid

4-(t-butyloxycarbonyl)morpholine-2-carboxylic acid methyl ester

methanol

2-carboxymorpholine acid

Downstream raw materials:

methyl 4-{3-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]propanoyl}-2-morpholinecarboxylate