(6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine

Base Information

Chemical Name:(6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine
CAS No.:1234356-69-4
Molecular Formula:C29H29FN4O
Molecular Weight:468.574
Hs Code.:
Mol file:1234356-69-4.mol

Synonyms:(6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine;ARQ-087

Suppliers and Price of (6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Derazantinib
1mg
$ 616.00

TRC
Derazantinib
2.5mg
$ 550.00

DC Chemicals
Derazantinib(ARQ087) >98%
250 mg
$ 1400.00

DC Chemicals
Derazantinib(ARQ087) >98%
1 g
$ 2800.00

ChemScene
Derazantinib 99.18%
100mg
$ 2880.00

ChemScene
Derazantinib 99.18%
50mg
$ 1680.00

ChemScene
Derazantinib 99.18%
10mg
$ 540.00

ChemScene
Derazantinib 99.18%
5mg
$ 348.00

ChemScene
Derazantinib 99.18%
25mg
$ 1080.00

Cayman Chemical
Derazantinib
25mg
$ 938.00

Total 18 raw suppliers

Chemical Property of (6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine

Chemical Property:

Boiling Point:615.1±65.0 °C(Predicted)
PKA:9.04±0.19(Predicted)
PSA：59.07000
Density:1.218±0.06 g/cm3(Predicted)
LogP:5.95670

Purity/Quality:

99%, ^*data from raw suppliers

Derazantinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Derazantinib is an intermediate in the preparation of imidazopyridinyl compounds for treating proliferative disorders like cancer, Proteus syndrome and others.

Technology Process of (6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine

There total 8 articles about (6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: C₂₆H₂₂FN₃O*ClH

: 124-63-0
methanesulfonyl chloride

: 109-85-3
2-methoxyethylamine

: 1234356-69-4
(R)-6-(2-fluorophenyl)-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

Guidance literature:: C₂₆H₂₂FN₃O*ClH; With sodium hydroxide; In 2-methyltetrahydrofuran; at 20 - 25 ℃; for 1h; Large scale;

methanesulfonyl chloride; With triethylamine; In 2-methyltetrahydrofuran; at 0 - 25 ℃; for 6h; Large scale;

2-methoxyethylamine; In 2-methyltetrahydrofuran; at 50 - 55 ℃; for 13h; Large scale;

Reference yield: 73.0%

: C₃₇H₃₅FN₄O₃

: 1234356-69-4
(R)-6-(2-fluorophenyl)-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

Guidance literature:: With palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 1282453-21-7
Missing (R)-2-((dimethylamino)methylene)-4-(2-fluorophenyl)-3,4-dihydronaphthalen-1(2H)-one

: 1234356-69-4
(R)-6-(2-fluorophenyl)-N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium ethanolate / 2-methyltetrahydrofuran; ethanol / 2 h / 20 - 25 °C / Large scale

1.2: 36 h / 75 - 80 °C / Large scale

1.3: 3.9 h / 60 - 65 °C / Large scale

2.1: sodium hydroxide / 2-methyltetrahydrofuran / 1 h / 20 - 25 °C / Large scale

2.2: 6 h / 0 - 25 °C / Large scale

2.3: 13 h / 50 - 55 °C / Large scale

With sodium ethanolate; sodium hydroxide; In 2-methyltetrahydrofuran; ethanol;