4-BroMo-3-iodo-benzoic acid Methyl ester

Base Information

• Chemical Name: 4-BroMo-3-iodo-benzoic acid Methyl ester
• CAS No.: 1257231-51-8
• Molecular Formula: C8H6BrIO2
• Molecular Weight: 340.943
• Hs Code.: 2916399090
• Mol file: 1257231-51-8.mol

Synonyms:4-BroMo-3-iodo-benzoic acid Methyl ester;Methyl4-bromo-3-iodobenzoate

Chemical Property of 4-BroMo-3-iodo-benzoic acid Methyl ester

Chemical Property:

• PSA: 26.30000
• LogP: 2.84030

Purity/Quality:

95% ^*data from raw suppliers

Methyl 4-bromo-3-iodobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-bromo-3-iodobenzoate

Technology Process of 4-BroMo-3-iodo-benzoic acid Methyl ester

There total 2 articles about 4-BroMo-3-iodo-benzoic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methanol (67-56-1) + 4-bromo-3-iodobenzoic acid (42860-06-0) → methyl 4-bromo-3-iodo-benzoate (1257231-51-8)

Guidance literature:

With sulfuric acid; for 12h; Inert atmosphere; Reflux;

DOI:10.1021/jo101953n

Reference yield: 73.0%

4-methoxycarbonylphenyl bromide (619-42-1) → methyl 4-bromo-3-iodo-benzoate (1257231-51-8)

Guidance literature:

With sodium periodate; sulfuric acid; iodine; at 20 ℃; for 1h;

DOI:10.1002/anie.202108814

Reference yield: 92.0%

methyl 4-bromo-3-iodo-benzoate (1257231-51-8) + propargyl alcohol methyl ether (627-41-8) → methyl 4-bromo-3-(3-methoxyprop-1-ynyl)benzoate (1257231-44-9)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diisopropylamine; for 12h; Inert atmosphere;

DOI:10.1021/jo101953n

upstream raw materials:

methanol

4-bromo-3-iodobenzoic acid

4-methoxycarbonylphenyl bromide

Downstream raw materials:

methyl 4-bromo-3-(3-methoxyprop-1-ynyl)benzoate

4-bromo-3-trifluoromethylbenzoic acid methyl ester

Refernces

• 1、 Djurdjevic, Sinisa,Yang, Fei,Green, James R.. "Intramolecular Nicholas reactions in the synthesis of dibenzocycloheptanes. Synthesis of allocolchicine NSC 51046 and analogues and the formal synthesis of (-)-allocolchicine". experimental part. p. 8241 - 8251. Retrieved 2011/03/18.