(E)-3-amino-3-(4-methoxyphenyl)-2-methylprop-2-enethioamide

Base Information

• Chemical Name: (E)-3-amino-3-(4-methoxyphenyl)-2-methylprop-2-enethioamide
• CAS No.: 1050392-22-7
• Molecular Formula: C₁₁H₁₄N₂OS
• Molecular Weight: 222.311
• Hs Code.: 2930909090
• Mol file: 1050392-22-7.mol

Synonyms:(E)-3-amino-3-(4-methoxyphenyl)-2-methylprop-2-enethioamide;3-Amino-3-(4-methoxyphenyl)-2-methyl-2-propenethioamide;2-PropenethioaMide, 3-aMino-3-(4-Methoxyphenyl)-2-Methyl-

Chemical Property of (E)-3-amino-3-(4-methoxyphenyl)-2-methylprop-2-enethioamide

Chemical Property:

• PSA: 97.90000
• Density: 1.192
• LogP: 3.09200
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-Amino-3-(4-methoxyphenyl)-2-methylprop-2-enethioamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-3-amino-3-(4-methoxyphenyl)-2-methylprop-2-enethioamide

There total 2 articles about (E)-3-amino-3-(4-methoxyphenyl)-2-methylprop-2-enethioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H12N2O (1050392-15-8) + thioacetamide (62-55-5) → C11H14N2OS (1050392-22-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.bmcl.2012.02.003

Reference yield:

4-methoxybenzonitrile (874-90-8) → C11H14N2OS (1050392-22-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium t-butanolate / tetrahydrofuran / 20 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1016/j.bmcl.2012.02.003

Reference yield:

C11H14N2OS (1050392-22-7) → 3-(4-methoxy-phenyl)-4-methylisothiazol-5-ylamine (1050392-29-4)

Guidance literature:

With dihydrogen peroxide; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2012.02.003

upstream raw materials:

C₁₁H₁₂N₂O

thioacetamide

4-methoxybenzonitrile

Downstream raw materials:

3-(4-methoxy-phenyl)-4-methylisothiazol-5-ylamine

Refernces