2-(4-Chlorophenyl)-1,1,1-trifluoroethane

Base Information

• Chemical Name: 2-(4-Chlorophenyl)-1,1,1-trifluoroethane
• CAS No.: 81577-07-3
• Molecular Formula: C8H6ClF3
• Molecular Weight: 194.584
• Mol file: 81577-07-3.mol

Synonyms:1-Chloro-4-(2,2,2-trifluoroethyl)benzene;2-(4-Chlorophenyl)-1,1,1-trifluoroethane

Chemical Property of 2-(4-Chlorophenyl)-1,1,1-trifluoroethane

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Chlorophenyl)-1,1,1-trifluoroethane

There total 17 articles about 2-(4-Chlorophenyl)-1,1,1-trifluoroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-chloro-4-(2,2-difluorovinyl)benzene (28321-09-7) → 1-chloro-4-(2,2,2-trifluoroethyl)benzene (81577-07-3)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; In N,N-dimethyl-formamide; at 70 ℃; for 5h;

Reference yield: 75.0%

4-Chlorophenylboronic acid (1679-18-1) + 2,2,2-trifluroethylamine hydrochloride (373-88-6) → 1-chloro-4-(2,2,2-trifluoroethyl)benzene (81577-07-3)

Guidance literature:

With ammonium chloride; sodium nitrite; In water; toluene; at 100 ℃; for 24h; Schlenk technique;

DOI:10.1002/ejoc.201402597

Reference yield: 75.0%

4-chlorobenzyl fluorosulfonyldifluoroacetate → 1-chloro-4-(2,2,2-trifluoroethyl)benzene (81577-07-3)

Guidance literature:

With copper(l) iodide; In N,N-dimethyl-formamide; at 60 ℃; for 8h;

DOI:10.1039/P19940000725

upstream raw materials:

1-chloro-1-(4-chlorophenyl)-2,2,2-trifluoroethane

1-chloro-4-(2,2-difluorovinyl)benzene

para-Chlorobenzyl alcohol

(1-(4-chlorophenyl)-2,2-difluorovinyl)triethylsilane

Downstream raw materials:

1-chloro-1-(4-chlorophenyl)-2,2,2-trifluoroethane

1-(1-bromo-2,2,2-trifluoroethyl)-4-chlorobenzene