2-Benzyloxazole

Base Information

• Chemical Name: 2-Benzyloxazole
• CAS No.: 68485-15-4
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Mol file: 68485-15-4.mol

Synonyms:2-Benzyloxazole

Chemical Property of 2-Benzyloxazole

Chemical Property:

• PSA: 26.03000
• LogP: 2.26540

Purity/Quality:

97% ^*data from raw suppliers

2-Benzyloxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Benzyloxazole

There total 8 articles about 2-Benzyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzylzinc chloride (89523-63-7) + 2-(methylthio)oxazole (201017-90-5) → 2-benzyl-oxazole (68485-15-4)

Guidance literature:

With bis(triphenylphosphine)nickel(II) chloride; In tetrahydrofuran; at 60 - 65 ℃; for 6h; Inert atmosphere;

DOI:10.1021/ol900260g

Reference yield: 45.3%

2-benzyloxazole-4-carboxylic acid (53697-48-6) → 2-benzyl-oxazole (68485-15-4)

Guidance literature:

With copper; at 250 ℃;

DOI:10.1021/jo951884l

Reference yield:

ethyl 2-benzyloxazole-4-carboxylate (68485-14-3) → 2-benzyl-oxazole (68485-15-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.9 percent / 6percent KOH / H₂O / 0.17 h / Heating

2: 45.3 percent / Cu / 250 °C

With potassium hydroxide; copper; In water;

DOI:10.1021/jo951884l

upstream raw materials:

2-benzyloxazole-4-carboxylic acid

2-trimethylsilyl-2H-1,2,3-triazole

phenylacetyl chloride

ethyl 2-benzyloxazole-4-carboxylate

Downstream raw materials:

4-benzyl-1,3-dihydro-furo[3,4-c]pyridin-7-ol

Refernces

• 1、 Abbotto, Alessandro,Bradamante, Silvia,Pagani, Giorgio A.. "Diheteroarylmethanes. 5. E-Z isomerism of carbanions substituted by 1,3-Azoles: 13C and 15N π-charge/shift relationships as source for mapping charge and ranking the electron-withdrawing power of heterocycles". . p. 1761 - 1769. Retrieved 2007/10/03.