(2'R)-2'-Deoxy-6-O-ethyl-2'-fluoro-2'-methylguanosine

Base Information

• Chemical Name: (2'R)-2'-Deoxy-6-O-ethyl-2'-fluoro-2'-methylguanosine
• CAS No.: 1199809-30-7
• Molecular Formula: C13H18FN5O4
• Molecular Weight: 327.315
• Mol file: 1199809-30-7.mol

Synonyms:(2'R)-2'-Deoxy-6-O-ethyl-2'-fluoro-2'-methylguanosine

Chemical Property of (2'R)-2'-Deoxy-6-O-ethyl-2'-fluoro-2'-methylguanosine

Chemical Property:

• PSA: 129.27000
• LogP: -0.28390

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2'R)-2'-Deoxy-6-O-ethyl-2'-fluoro-2'-methylguanosine

There total 17 articles about (2'R)-2'-Deoxy-6-O-ethyl-2'-fluoro-2'-methylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-(((4-chlorobenzoyl)oxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl 4-chlorobenzoate (1294481-82-5) + sodium ethanolate (141-52-6) → (2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol (1199809-30-7)

Guidance literature:

(2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-(((4-chlorobenzoyl)oxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl 4-chlorobenzoate; sodium ethanolate; In ethanol; at 20 ℃; for 1.5h; Inert atmosphere; Reflux;

With hydrogenchloride; In ethanol; water; at 20 ℃;

DOI:10.1021/jo200060f

Reference yield: 84.0%

ethanol (64-17-5) + (2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-(((4-chlorobenzoyl)oxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl 4-chlorobenzoate (1294481-82-5) → (2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol (1199809-30-7)

Guidance literature:

With sodium ethanolate; sodium hydride; In mineral oil; for 1h; Reflux;

Reference yield: 83.0%

(2R,3R,4R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate + sodium ethanolate (141-52-6) → (2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol (1199809-30-7) + C24H30F2N10O7

Guidance literature:

(2R,3R,4R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate; sodium ethanolate; In ethanol; for 1h; Reflux;

With hydrogenchloride; In ethanol; water; at 20 ℃;

DOI:10.1021/jo200060f

upstream raw materials:

ethanol

(2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate

((2R,3R,4R) 3-(4-chlorobenzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl-4-chlorobenzoate

((2R,3R,4R,5R)-3-((4-chlorobenzoyl)oxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl 4-chlorobenzoate

Downstream raw materials:

PSI-938

6-ethoxy-9-((2S,4aR,6R,7R,7aR)-7-fluoro-2-isopropoxy-7-methyl-2-oxo-tetrahydro-2λ(5)-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-9H-purin-2-ylamine

C₂₆H₂₇FN₅O₇P

C₄₁H₅₁FN₁₂O₁₃P₂