Methyl-((1Ξ,3R)-3-Methyl-cyclohexyl)-aMine

Base Information

• Chemical Name: Methyl-((1Ξ,3R)-3-Methyl-cyclohexyl)-aMine
• CAS No.: 90226-22-5
• Molecular Formula: C₈H₁₇N
• Molecular Weight: 127.23
• Hs Code.: 2921300090
• Mol file: 90226-22-5.mol

Synonyms:Methyl-((1Ξ,3R)-3-Methyl-cyclohexyl)-aMine

Chemical Property of Methyl-((1Ξ,3R)-3-Methyl-cyclohexyl)-aMine

Chemical Property:

• Vapor Pressure: 2.728mmHg at 25°C
• Boiling Point: 157.641°C at 760 mmHg
• Flash Point: 35.326°C
• PSA: 12.03000
• Density: 0.842g/cm³
• LogP: 2.17540

Purity/Quality:

N,3-DIMETHYLCYCLOHEXANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl-((1Ξ,3R)-3-Methyl-cyclohexyl)-aMine

There total 7 articles about Methyl-((1Ξ,3R)-3-Methyl-cyclohexyl)-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

→ N,3-dimethylcyclohexan-1-amine (90226-22-5)

Guidance literature:

Reference yield:

formic acid (64-18-6) + potassium formate (590-29-4) + 1,2,6-trimethyl-pyridinium; bromide (108249-54-3) → 1,2,6-trimethyl-1,2,3,6-tetrahydro-pyridine (856858-05-4,393531-22-1,556005-77-7) + N,3-dimethylcyclohexan-1-amine (90226-22-5) + cis-1,2,6-trimethylpiperidine (2439-13-6)

Guidance literature:

weitere Produkte: 3-Methyl-cyclohexanon; 3-Methyl-cyclohex-2-enon; Methylamin;

Reference yield:

methylamine (74-89-5) + 3-Methylcyclohexanone (591-24-2,625-96-7) → N,3-dimethylcyclohexan-1-amine (90226-22-5)

Guidance literature:

With acetic acid; In methanol; 1,2-dichloro-ethane; at 20 ℃; for 18h;

DOI:10.1021/jm1004286

upstream raw materials:

formic acid

potassium formate

1,2,6-trimethyl-pyridinium; bromide

methylamine

Downstream raw materials:

N-methyl-N-(3-methylcyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Refernces

• 1、 Flanagan, Mark E.,Blumenkopf, Todd A.,Brissette, William H.,Brown, Matthew F.,Casavant, Jeffrey M.,Shang-Poa, Chang,Doty, Jonathan L.,Elliott, Eileen A.,Fisher, Michael B.,Hines, Michael,Kent, Craig,Kudlacz, Elizabeth M.,Lillie, Brett M.,Magnuson, Kelly S.,McCurdy, Sandra P.,Munchhof, Michael J.,Perry, Bret D.,Sawyer, Perry S.,Strelevitz, Timothy J.,Subramanyam, Chakrapani,Sun, Jianmin,Whipple, David A.,Changelian, Paul S.. "Discovery of CP-690,550: A potent and selective janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection". experimental part. p. 8468 - 8484. Retrieved 2011/02/26.