methyl 4-(4-chlorophenyl)-5,6-dihydro-6,6-dimethyl-2H-pyran-3-carboxylate

Base Information

Chemical Name:methyl 4-(4-chlorophenyl)-5,6-dihydro-6,6-dimethyl-2H-pyran-3-carboxylate
CAS No.:1228783-97-8
Molecular Formula:C15H17ClO3
Molecular Weight:280.751
Hs Code.:
Mol file:1228783-97-8.mol

Synonyms:methyl 4-(4-chlorophenyl)-5,6-dihydro-6,6-dimethyl-2H-pyran-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-(4-chlorophenyl)-5,6-dihydro-6,6-dimethyl-2H-pyran-3-carboxylate

Chemical Property:

PSA：35.53000
LogP:3.46550

Purity/Quality:

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Technology Process of methyl 4-(4-chlorophenyl)-5,6-dihydro-6,6-dimethyl-2H-pyran-3-carboxylate

There total 3 articles about methyl 4-(4-chlorophenyl)-5,6-dihydro-6,6-dimethyl-2H-pyran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228783-96-7
methyl 6,6-dimethyl-4-(trifluoromethylsulfonyloxy)-5,6-dihydro-2H-pyran-3-carboxylate

: 1679-18-1
4-Chlorophenylboronic acid

: 1228783-97-8
methyl 4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; Reflux;

Reference yield:

: 1194-16-7
2,2-dimethyltetrahydropyran-4-one

: 1228783-97-8
methyl 4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; hexane / 0.5 h / 20 °C

1.2: 4 h / Reflux

2.1: sodium hydride / diethyl ether; mineral oil / 0.5 h / 0 °C

2.2: 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; In tetrahydrofuran; diethyl ether; hexane; toluene; mineral oil;

Reference yield:

: 1228386-26-2
methyl 6,6-dimethyl-4-oxotetrahydro-2H-pyran-3-carboxylate

: 1228783-97-8
methyl 4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / diethyl ether; mineral oil / 0.5 h / 0 °C

1.2: 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; In diethyl ether; toluene; mineral oil;