Methyl 1-methyl-indazole-5-carboxylate

Base Information

• Chemical Name: Methyl 1-methyl-indazole-5-carboxylate
• CAS No.: 1092351-82-0
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.1986
• Hs Code.: 2933998090
• Mol file: 1092351-82-0.mol

Synonyms:Methyl 1-methyl-indazole-5-carboxylate;methyl 1-methyl-1H-indazole-5-carboxylate;5-(Methoxycarbonyl)-1-methyl-1H-indazole;Methyl 1-Methyl-1H-indazol-5-carboxylate;1-Methyl-1H-indazole-5-carboxylic acid methyl ester

Chemical Property of Methyl 1-methyl-indazole-5-carboxylate

Chemical Property:

• PSA: 44.12000
• LogP: 1.35990
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Methyl1-Methyl-1H-indazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1-methyl-indazole-5-carboxylate

There total 7 articles about Methyl 1-methyl-indazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methanol (67-56-1) + 5-bromo-1-methyl-1H-indazole (465529-57-1) + carbon monoxide (201230-82-2) → methyl 1-methyl-1H-indazole-5-carboxylate (1092351-82-0)

Guidance literature:

With triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; at 100 ℃; for 24h; Product distribution / selectivity;

Reference yield: 75.0%

methyl 1H-indazole-5-carboxylate (473416-12-5) + methyl iodide (74-88-4) → methyl 1-methyl-1H-indazole-5-carboxylate (1092351-82-0)

Guidance literature:

methyl 1H-indazole-5-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 18h;

DOI:10.1021/jo500876q

Reference yield: 40.0%

methyl 1H-indazole-5-carboxylate (473416-12-5) + methyl iodide (74-88-4) → methyl 1-methyl-1H-indazole-5-carboxylate (1092351-82-0) + methyl 2-methyl-2H-indazole-5-carboxylate (1092351-86-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 50 ℃;

upstream raw materials:

methyl 1H-indazole-5-carboxylate

methyl iodide

methanol

5-bromo-1-methyl-1H-indazole

Downstream raw materials:

methyl 1-methyl-3,7-diphenyl-1H-indazole-5-carboxylate

methyl 1-methyl-3-phenyl-7-p-tolyl-1H-indazole-5-carboxylate

C₁₇H₁₆N₂O₃

ethyl 3-(1-methyl-1H-indazol-5-yl)-3-oxopropanoate

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