5-(benzyloxyMethyl)-4-Methoxy-5H-pyrrolo[3,2-d]pyriMidine

Base Information

• Chemical Name: 5-(benzyloxyMethyl)-4-Methoxy-5H-pyrrolo[3,2-d]pyriMidine
• CAS No.: 1026012-16-7
• Molecular Formula: C15H15N3O2
• Molecular Weight: 269.303
• Mol file: 1026012-16-7.mol

Synonyms:5-(benzyloxyMethyl)-4-Methoxy-5H-pyrrolo[3,2-d]pyriMidine;4-Methoxy-5-[(phenylmethoxy)methyl]-5H-pyrrolo[3,2-d]pyrimidine

Chemical Property of 5-(benzyloxyMethyl)-4-Methoxy-5H-pyrrolo[3,2-d]pyriMidine

Chemical Property:

• PSA: 49.17000
• LogP: 2.61420

Purity/Quality:

95%, 99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(benzyloxyMethyl)-4-Methoxy-5H-pyrrolo[3,2-d]pyriMidine

There total 8 articles about 5-(benzyloxyMethyl)-4-Methoxy-5H-pyrrolo[3,2-d]pyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

Benzyloxymethyl chloride (3587-60-8) + 4-chloropyrrolo[3,2-d]pyrimidine → 5-(benzyloxymethyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidine (1026012-16-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 4 ℃; for 2h; Inert atmosphere;

Reference yield:

methanol (67-56-1) + Benzyloxymethyl chloride (3587-60-8) + 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine (84905-80-6) → 5-(benzyloxymethyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidine (1026012-16-7)

Guidance literature:

Benzyloxymethyl chloride; 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

methanol; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

sodium methylate (124-41-4) + 5-benzyloxymethyl-4-chloro-5H-pyrrolo[3,2-d]pyrimidine → 5-(benzyloxymethyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidine (1026012-16-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; methanol; at 4 - 20 ℃;

upstream raw materials:

methanol

9-deazahypoxanthine

4-Chloro-5H-pyrrolo[3,2-d]pyrimidine

Benzyloxymethyl chloride

Downstream raw materials:

(2S,3S,4R,5R)-tert-butyl 2-(5-(benzyloxymethyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidine-1-carboxylate

(6aR,8S,9S,9aR)-tert-butyl 8-(5-(benzyloxymethyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-[1,3,5,2,4]trioxadisilocino[7,6-b]pyrrole-7(8H)-carboxylate

(6aR,8S,9R,9aR)-tert-butyl 8-(5-(benzyloxymethyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro[1,3,5,2,4]trioxadisilocino[7,6-d]pyrrole-7(8H)-carboxylate

(2S,3S,4R,5R)-tert-butyl 2-(5-((benzyloxy)methyl)-4-methoxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-dihydroxy-5-((trityloxy)methyl)pyrrolidine-1-carboxylate

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