4-(4-chlorophenyl)-5,6-dihydro-6,6-dimethyl-2H-Pyran-3-carboxaldehyde

Base Information

Chemical Name:4-(4-chlorophenyl)-5,6-dihydro-6,6-dimethyl-2H-Pyran-3-carboxaldehyde
CAS No.:1228783-99-0
Molecular Formula:C₁₄H₁₅ClO₂
Molecular Weight:250.725
Hs Code.:
Mol file:1228783-99-0.mol

Synonyms:4-(4-chlorophenyl)-5,6-dihydro-6,6-dimethyl-2H-Pyran-3-carboxaldehyde

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Chemical Property of 4-(4-chlorophenyl)-5,6-dihydro-6,6-dimethyl-2H-Pyran-3-carboxaldehyde

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Technology Process of 4-(4-chlorophenyl)-5,6-dihydro-6,6-dimethyl-2H-Pyran-3-carboxaldehyde

There total 6 articles about 4-(4-chlorophenyl)-5,6-dihydro-6,6-dimethyl-2H-Pyran-3-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.14%

: 1679-18-1
4-Chlorophenylboronic acid

: 4-bromo-6,6-dimethyl-2,5-dihydropyran-3-carbaldehyde

: 1228783-99-0
4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-carbaldehyde

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium methaneperoxoate sodium; In 1,2-dichloro-ethane; at 60 ℃; for 12h; Inert atmosphere;

Reference yield:

: 1228783-98-9
(4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl)methanol

: 1228783-99-0
4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-carbaldehyde

Guidance literature:: (4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-yl)methanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃;

With triethylamine; In dichloromethane;

Reference yield:

: 1194-16-7
2,2-dimethyltetrahydropyran-4-one

: 1228783-99-0
4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-pyran-3-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; hexane / 0.5 h / 20 °C

1.2: 4 h / Reflux

2.1: sodium hydride / diethyl ether; mineral oil / 0.5 h / 0 °C

2.2: 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene / Reflux

4.1: lithium aluminium tetrahydride / diethyl ether / 4 h

5.1: oxalyl dichloride / dichloromethane / 2.5 h / -78 °C

5.2: 20 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; sodium hydride; sodium carbonate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene; mineral oil;