Ethyl morpholinocarboxylate

Base Information

• Chemical Name: Ethyl morpholinocarboxylate
• CAS No.: 6976-49-4
• Molecular Formula: C7H13NO3
• Molecular Weight: 159.185
• Mol file: 6976-49-4.mol

Synonyms:Ethyl 4-morpholinecarboxylate;4-(ethoxycarbonyl)morpholine;N-ethoxycarbonylmorpholine;morpholine-4-carboxylic acid ethyl ester;Morpholin-4-carbonsaeure-aethylester;N-carboethoxymorpholine;ethyl morpholine-1-carboxylate;

Chemical Property of Ethyl morpholinocarboxylate

Chemical Property:

• Vapor Pressure: 0.0569mmHg at 25°C
• Refractive Index: n20/D1.459
• Boiling Point: 233.1°Cat760mmHg
• Flash Point: 94.8°C
• PSA: 38.77000
• Density: 1.115g/cm³
• LogP: 0.41300

Purity/Quality:

97% ^*data from raw suppliers

Ethyl morpholine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl morpholinocarboxylate

There total 2 articles about Ethyl morpholinocarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

morpholine (110-91-8,99108-56-2) + benzyl bromide (100-39-0) + diethyl dicarbonate (1609-47-8) → morpholine-4-carboxylic acid ethyl ester (6976-49-4) + benzyl ethyl carbonate (22768-02-1)

Guidance literature:

morpholine; With tert-butylammonium hexafluorophosphate(V); In acetonitrile; at 20 ℃; Electrolysis; Green chemistry;

diethyl dicarbonate; In acetonitrile; at 20 ℃; for 2h; Electrolysis; Green chemistry;

benzyl bromide; In acetonitrile; at 20 ℃; for 2h; Green chemistry;

DOI:10.1039/c9gc00707e

Reference yield:

morpholine (110-91-8,99108-56-2) + carbon dioxide (124-38-9,18923-20-1) + orthoformic acid triethyl ester (122-51-0) → N-Formylpiperidine (2591-86-8) + morpholine-4-carboxylic acid ethyl ester (6976-49-4)

Guidance literature:

at 120 ℃; for 45h; under 30400 Torr;

DOI:10.1246/bcsj.62.455

Reference yield: 72.0%

morpholine-4-carboxylic acid ethyl ester (6976-49-4) + benzylamine (100-46-9) → N-benzyl-N’,N’-morpholinylurea (69805-79-4)

Guidance literature:

With ethylmagnesium bromide; In tetrahydrofuran; dichloromethane; 5 deg C, then 48h reflux;

DOI:10.1016/S0040-4039(00)86102-X

upstream raw materials:

morpholine

carbon dioxide

orthoformic acid triethyl ester

benzyl bromide

Downstream raw materials:

N-benzyl-N’,N’-morpholinylurea

4-morpholinocarbonyl chloride