6976-49-4

Basic information

• Product Name: Ethyl morpholinocarboxylate
• Synonyms: Ethyl morpholinocarboxylate;Ethyl morpholine-4-carboxylate;Morpholine-4-carboxylic acid ethyl ester;N-(Ethoxycarbonyl)morpholine
• CAS NO: 6976-49-4
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.18302
• Mol File: 6976-49-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 233.1°Cat760mmHg
• Flash Point: 107℃
• Appearance: /
• Density: 1.091 at 25 °C
• Vapor Pressure: 0.0569mmHg at 25°C
• Refractive Index: n20/D1.459
• CAS DataBase Reference: Ethyl morpholinocarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl morpholinocarboxylate(6976-49-4)
• EPA Substance Registry System: Ethyl morpholinocarboxylate(6976-49-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 6976-49-4(Hazardous Substances Data)

Usage

General Description

Ethyl morpholinocarboxylate is a chemical compound that belongs to the class of organic compounds known as amino acids, peptides, and analogues. It is a derivative of morpholine and is commonly used as an intermediate in the synthesis of various pharmaceutical compounds. Ethyl morpholinocarboxylate is also used as a building block in the production of drug molecules and has potential applications in the field of medicinal chemistry. It is important to handle this chemical with care as it can be harmful if ingested, inhaled, or comes into contact with the skin or eyes. Due to its versatile nature and potential pharmaceutical applications, ethyl morpholinocarboxylate is an important chemical compound in the field of organic synthesis and drug development.

InChI:InChI=1/C7H13NO3/c1-2-11-7(9)8-3-5-10-6-4-8/h2-6H2,1H3

Upstream product

• 110-91-8 morpholine 
• 124-38-9 carbon dioxide 
• 122-51-0 orthoformic acid triethyl ester 
• 100-39-0 benzyl bromide 
• 1609-47-8 diethyl dicarbonate 

Downstream Products

• 69805-79-4 N-benzyl-N’,N’-morpholinylurea 
• 15159-40-7 4-morpholinocarbonyl chloride 

Relevant articles and documents

Electrochemical anion pool synthesis of amides with concurrent benzyl ester synthesis

An electrosynthesis method for amide bond formation has been developed in an attempt to increase the atom economy for this class of reactions. This "anion pool" method electrochemically generates strong nucleophiles from amine substrates. The amine nucleophiles then react with acid anhydrides to generate amides, and the by-product from this reaction undergoes further chemical transformations to generate pharmaceutically relevant benzoic esters. These one-pot reactions are operationally simple, are performed at room temperature, and avoid rare transition metals and added bases. The amide synthesis is amenable to primary and secondary amines and a variety of anhydrides with yields up to 90% obtained. Atom economy and process mass index (PMI) values calculated for this procedure indicate that this process can be considered greener compared to traditional amide synthesis routes used by industry. Furthermore, this electrochemical approach showed unique selectivity when substrates that contained two inequivalent amine moieties were examined.