Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate

Base Information

• Chemical Name: Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate
• CAS No.: 1150164-80-9
• Molecular Formula: C11H12F2O3
• Molecular Weight: 230.211
• Mol file: 1150164-80-9.mol

Synonyms:Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate;Difluoro-(2-Methoxy-phenyl)-acetic acid ethyl ester

Chemical Property of Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate

Chemical Property:

• PSA: 35.53000
• LogP: 2.35010
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 2,2-difluoro-2-(2-methoxyphenyl)acetate

Technology Process of Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate

There total 4 articles about Ethyl2,2-difluoro-2-(2-methoxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-iodoanisol (529-28-2) + Ethyl bromodifluoroacetate (667-27-6) → 2,2-difluoro-2-(2-methoxyphenyl)acetic acid ethyl ester (1150164-80-9)

Guidance literature:

With copper; In dimethyl sulfoxide; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1055/s-0035-1560592

Reference yield: 95.0%

→ 2,2-difluoro-2-(2-methoxyphenyl)acetic acid ethyl ester (1150164-80-9)

Guidance literature:

With copper; In dimethyl sulfoxide; at 30 - 50 ℃; for 16h; Inert atmosphere;

Reference yield:

methoxybenzene (100-66-3) + α-(trimethylsilyl)difluoroacetic acid ethyl ester (205865-67-4) → 2,2-difluoro-2-(3-methoxyphenyl)acetic acid ethyl ester (915133-57-2) + 2,2-difluoro-2-(2-methoxyphenyl)acetic acid ethyl ester (1150164-80-9) + 2,2-difluoro-2-(4-methoxyphenyl)acetic acid ethyl ester (112545-98-9)

Guidance literature:

With potassium fluoride; silver trifluoromethanesulfonate; In dichloromethane; at 85 ℃; for 24h; Overall yield = 96 %Spectr.; Sealed tube; Inert atmosphere;

DOI:10.1002/ejoc.201600770

upstream raw materials:

4-iodoanisol

Ethyl bromodifluoroacetate

methoxybenzene

α-(trimethylsilyl)difluoroacetic acid ethyl ester

Downstream raw materials:

1-methoxy-2-(trifluoromethyl)benzene

2,2-difluoro-2-(2-methoxyphenyl)acetic acid

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