1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl) ethanone

Base Information

• Chemical Name: 1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl) ethanone
• CAS No.: 1450657-28-9
• Molecular Formula: C12H16O5S
• Molecular Weight: 272.322
• Mol file: 1450657-28-9.mol

Synonyms:1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl) ethanone;1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethanone

Chemical Property of 1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl) ethanone

Chemical Property:

• PSA: 78.05000
• LogP: 2.40200
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl) ethanone

There total 14 articles about 1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl) ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

3-ethoxy-4-methoxy-acetophenone (31526-71-3) + methanesulfonyl chloride (124-63-0) → 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one (1450657-28-9)

Guidance literature:

3-ethoxy-4-methoxy-acetophenone; With n-butyllithium; In tetrahydrofuran; at -80 - -70 ℃; for 2h; Inert atmosphere;

methanesulfonyl chloride; In tetrahydrofuran; at -10 - 25 ℃; for 25h; Temperature; Inert atmosphere;

Reference yield: 96.6%

2-chloro-1-(3-ethoxy-4-methoxyphenyl)ethanone + methanesulfonic acid sodium salt (2386-57-4) → 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one (1450657-28-9)

Guidance literature:

In ethanol; for 15h; Reflux;

Reference yield: 95.0%

dimethylsulfone (67-71-0) + 3-ethoxy-4-methoxybenzoic acid methyl ester (97966-31-9) → 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one (1450657-28-9)

Guidance literature:

dimethylsulfone; With sodium hydride; In hexane; at 15 - 35 ℃; Inert atmosphere;

3-ethoxy-4-methoxybenzoic acid methyl ester; In hexane; at 30 - 35 ℃; for 6h; Solvent; Temperature; Reagent/catalyst; Inert atmosphere;

upstream raw materials:

methanesulfonic acid sodium salt

3-hydroxy-4-methoxyacetophenone

3-ethoxy-4-methoxy-acetophenone

dimethylsulfone

Downstream raw materials:

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate

(R)-3-ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzyl alcohol

(S)-4-(1-azido-2-(methylsulfonyl)ethyl)-2-ethoxy-1-methoxybenzene

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