1-Benzenesulfonyl-7-methoxy-1H-indole

Base Information

• Chemical Name: 1-Benzenesulfonyl-7-methoxy-1H-indole
• CAS No.: 146073-32-7
• Molecular Formula: C15H13NO3S
• Molecular Weight: 287.339
• DSSTox Substance ID: DTXSID90472434
• Nikkaji Number: J707.948F
• Wikidata: Q82301376
• Mol file: 146073-32-7.mol

Synonyms:146073-32-7;1-BENZENESULFONYL-7-METHOXY-1H-INDOLE;7-Methoxy-1-(phenylsulfonyl)-1H-indole;1-(benzenesulfonyl)-7-methoxy-1H-indole;1-(BENZENESULFONYL)-7-METHOXYINDOLE;MFCD11858413;7-Methoxy-1-(phenylsulfonyl)indole;SCHEMBL931908;DTXSID90472434;JPLYCGNNGYBEQO-UHFFFAOYSA-N;WFA07332;SB33696;SY286655;CS-0341560;FT-0765361;7-(Methyloxy)-1-(phenylsulfonyl)-1H-indole

Chemical Property of 1-Benzenesulfonyl-7-methoxy-1H-indole

Chemical Property:

• PSA: 56.68000
• LogP: 3.96770
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 287.06161445
• Heavy Atom Count: 20
• Complexity: 425

Purity/Quality:

97% ^*data from raw suppliers

1-Benzenesulfonyl-7-Methoxy-1h-Indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1N(C=C2)S(=O)(=O)C3=CC=CC=C3

Technology Process of 1-Benzenesulfonyl-7-methoxy-1H-indole

There total 5 articles about 1-Benzenesulfonyl-7-methoxy-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

7-methoxy-1H-indole (3189-22-8) + benzenesulfonyl chloride (98-09-9) → 7-(methyloxy)-1-(phenylsulfonyl)-1H-indole (146073-32-7)

Guidance literature:

7-methoxy-1H-indole; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

benzenesulfonyl chloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield: 69.0%

3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl-2-pyrrolyl)-1-propanone (146073-29-2) + trimethyl orthoformate (149-73-5) → 7-(methyloxy)-1-(phenylsulfonyl)-1H-indole (146073-32-7)

Guidance literature:

With sulfuric acid; for 3.5h; Heating;

DOI:10.1248/cpb.40.2344

Reference yield:

benzenesulfonyl chloride (98-09-9) → 7-(methyloxy)-1-(phenylsulfonyl)-1H-indole (146073-32-7)

Guidance literature:

7-methoxy-1H-indole; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

benzenesulfonyl chloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

upstream raw materials:

7-methoxy-1H-indole

benzenesulfonyl chloride

3-(1,3-dioxolan-2-yl)-1-(phenylsulfonyl-2-pyrrolyl)-1-propanone

trimethyl orthoformate

Downstream raw materials:

methyl 7-(methyloxy)-1-(phenylsulfonyl)-1H-indole-4-carboxylate

7-methoxy-4-nitro-1H-indole

(5-benzyloxy-1-phenylsulfonyl-1H-indol-2-yl)-(7-methoxy-1-phenylsulfonyl-1H-indol-2-yl)methanone

1-benzenesulfonyl-7-methoxy-4-nitro-1H-indole

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