9-Fluorenone oxime

Base Information

• Chemical Name: 9-Fluorenone oxime
• CAS No.: 2157-52-0
• Molecular Formula: C13H9NO
• Molecular Weight: 195.221
• Hs Code.: 29221990
• European Community (EC) Number: 218-471-8
• NSC Number: 1988
• UNII: BQN5AH5VZJ
• DSSTox Substance ID: DTXSID50175919
• Nikkaji Number: J69.732J
• ChEMBL ID: CHEMBL1492999
• Mol file: 2157-52-0.mol

Synonyms:9-fluorenone oxime;fluorenone oxime

Chemical Property of 9-Fluorenone oxime

Chemical Property:

• Vapor Pressure: 6.45E-07mmHg at 25°C
• Melting Point: 193-194°C
• Refractive Index: 1.663
• Boiling Point: 394.1 °C at 760 mmHg
• PKA: 10.81±0.20(Predicted)
• Flash Point: 252.2 °C
• PSA: 32.59000
• Density: 1.23g/cm³
• LogP: 2.89360
• Storage Temp.: Keep Cold
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 195.068413911
• Heavy Atom Count: 15
• Complexity: 250

Purity/Quality:

98%,99%, ^*data from raw suppliers

9-Fluorenone Oxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3C2=NO

Technology Process of 9-Fluorenone oxime

There total 38 articles about 9-Fluorenone oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

9-fluorenone (486-25-9,952573-42-1) → 9-fluorenone oxime (2157-52-0)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; at 50 - 60 ℃; for 1h;

DOI:10.1002/jccs.201200011

Reference yield: 85.0%

3',4',4'-triphenylfluorene-9-spiro-2'-oxazolidin-5'-one (76013-19-9) → 9-fluorenone oxime (2157-52-0) + anilino-diphenyl-acetic acid (1922-78-7)

Guidance literature:

With hydroxylamine; In methanol; at 60 ℃; for 18h;

Reference yield: 85.0%

4'-cyano-3'-phenyl-4'-t-butylfluorene-9-spiro-2'-oxazolidin-5'-one (92592-27-3) → 9-fluorenone oxime (2157-52-0)

Guidance literature:

With hydroxylamine; In methanol; for 0.5h; Heating;

upstream raw materials:

2-iodo-propane

ethyl bromide

ethanol

9-nitro-fluorene

Downstream raw materials:

6(5H)-phenanthridinone

phenanthridin-6-ol

tetrabenzo[5.5]fulvalene

spiro[9H-fluorene-9,9'(10'H)-phenanthrene]-10'-one

Refernces

• 1、 Koelsch. "". . p. 1291. Retrieved 1961.
• 2、 Spiegler. "-". . p. 203. Retrieved 1884.
• 3、 Aggarwal, Himanshu,Bala?a-Fouce, Rafael,Chandra Sekhar, Kondapalli Venkata Gowri,Karan Kumar, Banoth,Melcón-Fernandez, Estela,Murugesan, Sankaranarayanan,Nandikolla, Adinarayana,Pérez-Pertejo, Yolanda,Srinivasarao, Singireddi. "Novel phenanthridine amide analogs as potential anti-leishmanial agents: In vitro and in silico insights". supporting information. . Retrieved 2021/11/01.
• 4、 Kürti, László,Kattamuri, Padmanabha V.,Siitonen, Juha H.,Yousufuddin, Muhammed. "Arylboronic Acid-Catalyzed C-Allylation of Unprotected Oximes: Total Synthesis of N-Me-Euphococcine". supporting information. . Retrieved 2020/03/24.