Ethyl 2-methyl-4-phenylpyrimidine-5-carboxylate

Base Information

Chemical Name:Ethyl 2-methyl-4-phenylpyrimidine-5-carboxylate
CAS No.:127957-93-1
Molecular Formula:C14H14N2O2
Molecular Weight:242.27
Hs Code.:2933599090
DSSTox Substance ID:DTXSID80562454
Nikkaji Number:J284.719A
Wikidata:Q82446619
Mol file:127957-93-1.mol

Synonyms:127957-93-1;ethyl 2-methyl-4-phenylpyrimidine-5-carboxylate;ETHYL-2-METHYL-4-PHENYL-5-PYRIMIDINE CARBOXYLATE;5-Pyrimidinecarboxylic acid, 2-methyl-4-phenyl-, ethyl ester;2-methyl-4-phenyl-pyrimidine-5-carboxylic acid ethyl ester;SCHEMBL1965857;DTXSID80562454;DNDJARWVBDEYEW-UHFFFAOYSA-N;ethyl2-methyl-4-phenylpyrimidine-5-carboxylate

Suppliers and Price of Ethyl 2-methyl-4-phenylpyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ETHYL-2-METHYL-4-PHENYL-5-PYRIMIDINE CARBOXYLATE 98.00%
5MG
$ 498.91

Total 2 raw suppliers

Chemical Property of Ethyl 2-methyl-4-phenylpyrimidine-5-carboxylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:389.185°C at 760 mmHg
Flash Point:189.172°C
PSA：52.08000
Density:1.144g/cm³
LogP:2.62870
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:242.105527694
Heavy Atom Count:18
Complexity:277

Purity/Quality:

95% ^*data from raw suppliers

ETHYL-2-METHYL-4-PHENYL-5-PYRIMIDINE CARBOXYLATE 98.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN=C(N=C1C2=CC=CC=C2)C

Technology Process of Ethyl 2-methyl-4-phenylpyrimidine-5-carboxylate

There total 3 articles about Ethyl 2-methyl-4-phenylpyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 66129-60-0
ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate

: 143-37-3
acetamidine

: 127957-93-1
2-methyl-4-phenyl-pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: With sodium ethanolate; In ethanol; for 24h; Heating;

Reference yield:

: 124-42-5
acetamidine hydrochloride

: 66129-60-0
ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate

: 127957-93-1
2-methyl-4-phenyl-pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: acetamidine hydrochloride; With sodium ethanolate; In ethanol; for 0.5h; Inert atmosphere;

ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate; In ethanol; Reflux;

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 127957-93-1
2-methyl-4-phenyl-pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-dioxane / 7 h / 100 °C

2: sodium methylate / methanol / 4 h / 80 °C

With sodium methylate; In 1,4-dioxane; methanol;
DOI:10.1016/j.bmcl.2012.08.070