Methyl 2-bromo-4-fluoro-5-methoxybenzoate

Base Information

• Chemical Name: Methyl 2-bromo-4-fluoro-5-methoxybenzoate
• CAS No.: 1007455-22-2
• Molecular Formula: C9H8BrFO3
• Molecular Weight: 263.063
• Hs Code.: 2916310090
• Mol file: 1007455-22-2.mol

Synonyms:Methyl 2-bromo-4-fluoro-5-methoxybenzoate;2-Bromo-4-fluoro-5-methoxy-benzoic acid methyl ester

Chemical Property of Methyl 2-bromo-4-fluoro-5-methoxybenzoate

Chemical Property:

• PSA: 35.53000
• LogP: 2.38340

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-bromo-4-fluoro-5-methoxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-Bromo-4-fluoro-5-methoxybenzoate is a useful compound for preparing fluorogenic probes.

Technology Process of Methyl 2-bromo-4-fluoro-5-methoxybenzoate

There total 2 articles about Methyl 2-bromo-4-fluoro-5-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 2-bromo-4-fluoro-5-methoxy-benzoic acid (1007455-21-1) → methyl 2-bromo-4-fluoro-5-methoxybenzoate (1007455-22-2)

Guidance literature:

With sulfuric acid; for 7.5h; Reflux;

Reference yield:

4?fluoro-3-methoxybenzoic acid (82846-18-2) → methyl 2-bromo-4-fluoro-5-methoxybenzoate (1007455-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; acetic acid / water / 60 °C

2: sulfuric acid / 7.5 h / Reflux

With sulfuric acid; bromine; acetic acid; In water;

Reference yield: 81.0%

methyl 2-bromo-4-fluoro-5-methoxybenzoate (1007455-22-2) + copper(l) cyanide → methyl 2-cyano-4-fluoro-5-methoxybenzoate (1007455-23-3)

Guidance literature:

In N,N-dimethyl-formamide; at 150 ℃; for 4h;

upstream raw materials:

methanol

2-bromo-4-fluoro-5-methoxy-benzoic acid

4?fluoro-3-methoxybenzoic acid

Downstream raw materials:

methyl 2-cyano-4-fluoro-5-methoxybenzoate

5-fluoro-6-methoxyisoindolin-1-one