1-(tert-butoxycarbonyl)-4-(phenylaMino)piperidine-4-carboxylic acid

Base Information

• Chemical Name: 1-(tert-butoxycarbonyl)-4-(phenylaMino)piperidine-4-carboxylic acid
• CAS No.: 1159835-31-0
• Molecular Formula: C17H24N2O4
• Molecular Weight: 320.389
• Hs Code.: 2933399090
• Mol file: 1159835-31-0.mol

Synonyms:1-(tert-butoxycarbonyl)-4-(phenylaMino)piperidine-4-carboxylic acid

Chemical Property of 1-(tert-butoxycarbonyl)-4-(phenylaMino)piperidine-4-carboxylic acid

Chemical Property:

• Boiling Point: 490.4±45.0 °C(Predicted)
• PKA: 1.99±0.20(Predicted)
• PSA: 78.87000
• Density: 1.230±0.06 g/cm3(Predicted)
• LogP: 2.96370

Purity/Quality:

99% ^*data from raw suppliers

Ph-NH-Pip(Boc)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(tert-butoxycarbonyl)-4-(phenylaMino)piperidine-4-carboxylic acid

There total 2 articles about 1-(tert-butoxycarbonyl)-4-(phenylaMino)piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

chloroform (67-66-3,8013-54-5) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + aniline (62-53-3) → 1-(tert-butoxycarbonyl)-4-(phenylamino)piperidine-4-carboxylic acid (1159835-31-0)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 64.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + ethyl acetate (141-78-6) + aniline (62-53-3) → 1-(tert-butoxycarbonyl)-4-(phenylamino)piperidine-4-carboxylic acid (1159835-31-0)

Guidance literature:

N-tert-butyloxycarbonylpiperidin-4-one; aniline; With sodium hydroxide; In tetrahydrofuran; chloroform; at 0 - 20 ℃; for 13h;

ethyl acetate; With water;

Reference yield: 88.5%

Methyl methanesulfonate (66-27-3) + 1-(tert-butoxycarbonyl)-4-(phenylamino)piperidine-4-carboxylic acid (1159835-31-0) → 1-(tert-butyl) 4-methyl 4-(phenylamino)piperidine-1,4-dicarboxylate

Guidance literature:

1-(tert-butoxycarbonyl)-4-(phenylamino)piperidine-4-carboxylic acid; With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 1h;

Methyl methanesulfonate; In dimethyl sulfoxide; at 20 ℃; for 12h;

upstream raw materials:

chloroform

N-tert-butyloxycarbonylpiperidin-4-one

aniline

ethyl acetate

Downstream raw materials:

1-tert-butyl 4-methyl 4-(N-phenylpropionamido)piperidine-1,4-dicarboxylate

4-(Methoxymethyl)-N-phenyl-1-<2-(2-thienyl)ethyl>-4-piperidinamine

sufentanil

sufentanil citrate