Technology Process of 3,4-Difluoro-2-methoxybenzaldehyde
There total 2 articles about 3,4-Difluoro-2-methoxybenzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2.3-difluoroanisole;
With
titanium tetrachloride;
In
dichloromethane;
at 0 ℃;
for 0.0833333h;
Dichloromethyl methyl ether;
In
dichloromethane;
at 20 ℃;
for 0.5h;
DOI:10.1016/S0022-1139(03)00117-9
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 78 percent / K2CO3 / dimethylsulfoxide / 0.5 h / 20 °C
2.1: TiCl4 / CH2Cl2 / 0.08 h / 0 °C
2.2: 3 percent / CH2Cl2 / 0.5 h / 20 °C
With
titanium tetrachloride; potassium carbonate;
In
dichloromethane; dimethyl sulfoxide;
2.2: Friedel-Crafts formylation;
DOI:10.1016/S0022-1139(03)00117-9
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 0.5 h / -50 °C / Inert atmosphere
1.2: 1 h / -40 °C
2.1: trifluoroacetic acid; chlorotriisopropylsilane / tetrahydrofuran / 2 h / 70 °C
3.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 5 h / 100 °C
4.1: 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 0.5 h / -40 °C
4.2: 1 h / -20 °C
With
tetrakis(triphenylphosphine) palladium(0); chlorotriisopropylsilane; 2,2,6,6-tetramethylpiperidinyl-lithium; trifluoroacetic acid;
In
tetrahydrofuran; N,N-dimethyl-formamide;
