AS1940477

Base Information

• Chemical Name: AS1940477
• CAS No.: 928344-12-1
• Molecular Formula: C₂₄H₂₂FN₅O₂
• Molecular Weight: 0
• Mol file: 928344-12-1.mol

Synonyms:AS1940477

Chemical Property of AS1940477

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of AS1940477

There total 38 articles about AS1940477 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

(R)-6-{6-[(benzyloxy)methyl]-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl}-2-(2-tolyl)-2,3-dihydropyridazin-3-one (1404166-77-3) → A(404)S1977 (928344-12-1)

Guidance literature:

With hydrogenchloride; water; In ethanol; at 45 - 60 ℃; for 24h; Large scale;

DOI:10.1021/op300237b

Reference yield: 82.0%

ethyl 2-(4-fluorophenyl)-3-[1-(2-methylphenyl)-6-oxo-1,6-dihydropyridazin-3-yl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-6-carboxylate → 6-[2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (928343-61-7,928344-12-1,928344-13-2)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/jm3008008

Reference yield:

6-[2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (928343-61-7,928344-12-1,928344-13-2) → A(404)S1977 (928344-12-1) + (S)-6-[2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-tolyl)-2,3-dihydropyridazin-3-one (928344-13-2)

Guidance literature:

With DAICEL Chiralcel OJ-H column (25 cm × 0.46 cm); In methanol; ethanol; hexane; isopropyl alcohol; acetonitrile; at 40 ℃; for 0.5h; Resolution of racemate;

DOI:10.1021/jm3008008

upstream raw materials:

ethyl 3-{[tert-butyl(dimethyl)silyl]oxy}-2-{[(phenoxycarbothioyl)amino]methyl}propanoate

ethyl 3-{[tert-butyl(dimethyl)silyl]oxy}-2-{[(hydrazinocarbothioyl)amino]methyl}propanoate

3-chloro-6-methylpyridazine

ethyl 3-({3-(4-fluorophenyl)-4-[1-(2-methylphenyl)-6-oxo-1,6-dihydropyridazin-3-yl]-1H-pyrazol-5-yl}amino)-2-(hydroxymethyl)propanoate

Downstream raw materials:

6-[2-(4-fluorophenyl)-6-(iodomethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one

(S)-6-[2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-tolyl)-2,3-dihydropyridazin-3-one

6-[2-(4-fluorophenyl)-6-methylene-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one

(R)-6-[2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-tolyl)-2,3-dihydropyridazin-3-one monohydrobromide