(E)-3-(2-fluorophenyl)-2-Methylacrylaldehyde

Base Information

• Chemical Name: (E)-3-(2-fluorophenyl)-2-Methylacrylaldehyde
• CAS No.: 1375800-37-5
• Molecular Formula: C10H9FO
• Molecular Weight: 164.179
• Mol file: 1375800-37-5.mol

Synonyms:(E)-3-(2-fluorophenyl)-2-Methylacrylaldehyde

Chemical Property of (E)-3-(2-fluorophenyl)-2-Methylacrylaldehyde

Chemical Property:

• PSA: 17.07000
• LogP: 2.42790

Purity/Quality:

97% ^*data from raw suppliers

(E)-3-(2-Fuorophenyl)-2-methylacrylaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-3-(2-fluorophenyl)-2-Methylacrylaldehyde

There total 5 articles about (E)-3-(2-fluorophenyl)-2-Methylacrylaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

propionaldehyde (123-38-6) + 2-Fluorobenzaldehyde (446-52-6) → (E)-3-(2-fluorophenyl)-2-methylacrylaldehyde (1375800-37-5)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.02.041

Reference yield: 18.0%

fluorobenzene (462-06-6) + isobutyraldehyde (78-84-2) → 3-(4-fluorophenyl)-2-methyl-2-propen-1-al (125265-16-9,78495-95-1) + (E)-3-(2-fluorophenyl)-2-methylacrylaldehyde (1375800-37-5)

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; trifluoroacetic acid; 3-amino propanoic acid; at 60 ℃; for 24h; stereoselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.9b00695

Reference yield:

C10H11FO → (E)-3-(2-fluorophenyl)-2-methylacrylaldehyde (1375800-37-5)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1002/adsc.202000831

upstream raw materials:

propionaldehyde

2-Fluorobenzaldehyde

fluorobenzene

isobutyraldehyde

Downstream raw materials:

(E)-3-(2-fluorophenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine

VUF₁₁₂₀₇

VUF₁₁₄₀₃

Refernces

• 1、 Zhang, Xing-Long,Pan, Gao-Fei,Zhu, Xue-Qing,Guo, Rui-Li,Gao, Ya-Ru,Wang, Yong-Qiang. "Dehydrogenative β-Arylation of Saturated Aldehydes Using Transient Directing Groups". supporting information. p. 2731 - 2735. Retrieved 2019/04/30.