α-Methylbenzenebutyric acid methyl ester

Base Information

• Chemical Name: α-Methylbenzenebutyric acid methyl ester
• CAS No.: 20881-29-2
• Molecular Formula: C12H16O2
• Molecular Weight: 192.258
• Mol file: 20881-29-2.mol

Synonyms:4-Phenyl-2-methylbutanoic acid methyl ester;α-Methylbenzenebutanoic acid methyl ester;α-Methylbenzenebutyric acid methyl ester;4-Phenylpentanoic acid methyl ester;4-Phenylvaleric acid methyl ester

Chemical Property of α-Methylbenzenebutyric acid methyl ester

Chemical Property:

• PSA: 26.30000
• LogP: 2.74330

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of α-Methylbenzenebutyric acid methyl ester

There total 12 articles about α-Methylbenzenebutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(E)-methyl 5,5-dibromo-4-phenylpenta-2,4-dienoate → dihydro-α-norcurcumenic acid methylester (20881-29-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h;

DOI:10.1002/anie.201608371

Reference yield: 92.0%

methanol (67-56-1) + 4-phenyl-1-pentanoic acid (16433-43-5) → dihydro-α-norcurcumenic acid methylester (20881-29-2)

Guidance literature:

With acetyl chloride;

DOI:10.1021/ja00350a042

Reference yield: 87.0%

Methyl thioglycolate (2365-48-2) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → dihydro-α-norcurcumenic acid methylester (20881-29-2)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); triethyl phosphite; In 1,2-dichloro-ethane; at 80 ℃; for 12h; under 760.051 Torr; Inert atmosphere; Schlenk technique;

DOI:10.1039/c9cc05378f

upstream raw materials:

methanol

4-phenyl-1-pentanoic acid

5-methyl-5-phenyl-dihydro-furan-2-one

pent-4-enoic acid

Downstream raw materials:

4-phenyl-1-pentanoic acid

1,1-dimethyl-4-phenylpentanol

methyl 4-(4-acetylphenyl)pentanoate

1,1,4-trimethyl-tetralin