2-hydroxy-N'-(2-thienylmethylene)benzohydrazide

Base Information

• Chemical Name: 2-hydroxy-N'-(2-thienylmethylene)benzohydrazide
• CAS No.: 93352-51-3
• Molecular Formula: C12H10N2O2S
• Molecular Weight: 246.29
• European Community (EC) Number: 658-981-1
• Nikkaji Number: J2.457.326E
• Wikidata: Q76393279
• Mol file: 93352-51-3.mol

Synonyms:2-hydroxy-N'-(2-thienylmethylene)benzohydrazide;BDBM193694;SALOR-INT L496979-1EA;2-Hydroxy-N'-[(Z)-2-thienylmethylidene]benzohydrazide (23)

Chemical Property of 2-hydroxy-N'-(2-thienylmethylene)benzohydrazide

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 246.04629874
• Heavy Atom Count: 17
• Complexity: 296

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NN=CC2=CC=CS2)O
• Isomeric SMILES: C1=CC=C(C(=C1)C(=O)N/N=C\C2=CC=CS2)O

Technology Process of 2-hydroxy-N'-(2-thienylmethylene)benzohydrazide

There total 2 articles about 2-hydroxy-N'-(2-thienylmethylene)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.74%

thiophene-2-carbaldehyde (98-03-3) + 2-Hydroxybenzoylhydrazine (936-02-7) → 2‐hydroxy‐N′‐(thiophene‐2‐methylene)‐2‐benzoylhydrazine (93352-51-3)

Guidance literature:

In ethanol; for 2h; Reflux;

DOI:10.14233/ajchem.2015.18896

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → 2‐hydroxy‐N′‐(thiophene‐2‐methylene)‐2‐benzoylhydrazine (93352-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 4 h / Reflux

2: ethanol / 5 h / Reflux

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.molstruc.2012.11.032

Reference yield: 80.0%

methanol (67-56-1) + vanadium(IV) oxide sulfate hydrate (12440-03-8,772292-34-9,121437-28-3,22534-68-5) + 2‐hydroxy‐N′‐(thiophene‐2‐methylene)‐2‐benzoylhydrazine (93352-51-3) → C28H30N4O10S2V2

Guidance literature:

With triethylamine; at 20 ℃; for 3h;

DOI:10.1016/j.poly.2017.01.054

upstream raw materials:

thiophene-2-carbaldehyde

2-Hydroxybenzoylhydrazine

methyl salicylate