3-triMethylsilyloxy-7-ketolithocholic Methyl ester

Base Information

Chemical Name:3-triMethylsilyloxy-7-ketolithocholic Methyl ester
CAS No.:77341-09-4
Molecular Formula:C28H48O5Si
Molecular Weight:476.772
Hs Code.:
Mol file:77341-09-4.mol

Synonyms:3-triMethylsilyloxy-7-ketolithocholic Methyl ester;Obeticholic Acid Intermediate

Suppliers and Price of 3-triMethylsilyloxy-7-ketolithocholic Methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl3-Trimethylsilyloxy-7-ketolithocholate
500mg
$ 790.00

Crysdot
(R)-Methyl4-((3R,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-7-oxo-3-((trimethylsilyl)oxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate 95+%
250mg
$ 452.00

Crysdot
(R)-Methyl4-((3R,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-7-oxo-3-((trimethylsilyl)oxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate 95+%
1g
$ 1131.00

Chemenu
(R)-Methyl4-((3R,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-7-oxo-3-((trimethylsilyl)oxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate 95%
1g
$ 1066.00

Total 6 raw suppliers

Chemical Property of 3-triMethylsilyloxy-7-ketolithocholic Methyl ester

Chemical Property:

PSA：52.60000
LogP:6.63370

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-Trimethylsilyloxy-7-ketolithocholate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Methyl 3-Trimethylsilyloxy-7-ketolithocholate is used as a reactant in the preparation of Obeticholic Acid.

Technology Process of 3-triMethylsilyloxy-7-ketolithocholic Methyl ester

There total 4 articles about 3-triMethylsilyloxy-7-ketolithocholic Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: 10538-59-7
7-ketolithocholic methyl ester

: 77341-09-4
methyl 3α-(trimethylsilyloxy)-7-keto-5β-cholan-24-oate

Guidance literature:: With triethylamine; In toluene; at 70 - 80 ℃; for 1h; Large scale;

Reference yield:

: 10416-59-8
N,O-bis-(trimethylsilyl)-acetamide

: 10538-59-7
7-ketolithocholic methyl ester

: 77341-09-4
methyl 3α-(trimethylsilyloxy)-7-keto-5β-cholan-24-oate

Guidance literature:: In acetonitrile; at 20 ℃; for 15h;

Reference yield:

: 4651-67-6
7-Ketolithocholic acid

: 77341-09-4
methyl 3α-(trimethylsilyloxy)-7-keto-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 2 steps

1: methanesulfonic acid / 1 h / 30 - 60 °C / Large scale

2: triethylamine / toluene / 1 h / 70 - 80 °C / Large scale

With methanesulfonic acid; triethylamine; In toluene;