diethyl 2,2-difluoropentanedioate

Base Information

• Chemical Name: diethyl 2,2-difluoropentanedioate
• CAS No.: 428-97-7
• Molecular Formula: C9H14F2O4
• Molecular Weight: 224.205
• Hs Code.: 2918199890
• Mol file: 428-97-7.mol

Synonyms:diethyl 2,2-difluoropentanedioate

Chemical Property of diethyl 2,2-difluoropentanedioate

Chemical Property:

• Boiling Point: 127-128 °C(Press: 28 Torr)
• PSA: 52.60000
• Density: 1.149±0.06 g/cm3(Predicted)
• LogP: 1.52810
• Storage Temp.: 2-8°C

Purity/Quality:

≥95% ^*data from raw suppliers

Diethyl2,2-Difluoropentanedioate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl 2,2-difluoropentanedioate

There total 6 articles about diethyl 2,2-difluoropentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.4%

Ethyl bromodifluoroacetate (667-27-6) + ethyl acrylate (140-88-5,9003-32-1) → 2,2-difluoroglutaric acid diethyl ester (428-97-7)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; copper; acetic acid; In tetrahydrofuran; at 50 ℃; for 0.5h; Reagent/catalyst;

Reference yield: 92.7%

sodium ethanolate (141-52-6) + 3,3-Difluor-1-cyclopenten (80997-33-7) → 2,2-difluoroglutaric acid diethyl ester (428-97-7)

Guidance literature:

With ozone; In dichloromethane; at -20 ℃; for 0.833333h; Solvent;

Reference yield: 15.0%

Ethyl bromodifluoroacetate (667-27-6) + ethyl acrylate (140-88-5,9003-32-1) → 2,2-difluoroglutaric acid diethyl ester (428-97-7) + C12H18F2O6 (1412175-17-7)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; copper; In tetrahydrofuran;

DOI:10.1055/s-0032-1317134

upstream raw materials:

ethanol

2,2-difluoroglutaric acid

diethyl 2-ketoglutarate

Ethyl bromodifluoroacetate

Downstream raw materials:

3-t-butoxycarbonylamino-4-(5,5-difluoro-2-oxo-piperidin-1-yl)butyric acid

ethyl 4,4-difluoro-5-hydroxypentanoate

Refernces

• 1、 -. "Synthesis method of dialkyl 2,2-difluorodicarboxylate". Paragraph 0040-0044. . Retrieved 2018/07/15.
• 2、 -. "PRODUCTION METHOD OF INTERMEDIATE COMPOUND FOR SYNTHESIZING MEDICAMENT". Paragraph 0098; 0099; 0100. . Retrieved 2013/07/05.