1-Benzyl 3-Methyl 5-(N-BOC-aMino)piperidin-1,3-dicarboxylate

Base Information

• Chemical Name: 1-Benzyl 3-Methyl 5-(N-BOC-aMino)piperidin-1,3-dicarboxylate
• CAS No.: 1221819-24-4
• Molecular Formula: C₂₀H₂₈N₂O₆
• Molecular Weight: 392.452
• Hs Code.: 2933399090
• Mol file: 1221819-24-4.mol

Synonyms:1-Benzyl 3-Methyl 5-(N-BOC-aMino)piperidin-1,3-dicarboxylate

Chemical Property of 1-Benzyl 3-Methyl 5-(N-BOC-aMino)piperidin-1,3-dicarboxylate

Chemical Property:

• PSA: 94.17000
• LogP: 3.04020

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl 3-methyl 5-(tert-butoxycarbonylamino)-piperidine-1,3-dicarboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzyl 3-Methyl 5-(N-BOC-aMino)piperidin-1,3-dicarboxylate

There total 9 articles about 1-Benzyl 3-Methyl 5-(N-BOC-aMino)piperidin-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.02%

1-((benzyloxy)carbonyl)-5-(methoxycarbonyl)piperidine-3-carboxylic acid + tert-butyl alcohol (75-65-0) → 1-benzyl 3-methyl 5-((tert-butoxycarbonyl)amino)piperidine-1,3-dicarboxylate (1221819-24-4)

Guidance literature:

With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine; at 100 ℃; for 8h;

Reference yield:

methanol (67-56-1) + cis-(+/-)-1-(benzyloxycarbonyl)-5-(tert-butoxycarbonylamino)-piperidine-3-carboxylic acid → cis-(+/-)-1-benzyl 3-methyl 5-(tert-butoxycarbonylamino)-piperidine-1,3-dicarboxylate (1221819-24-4)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; ethyl acetate; at 0 ℃; for 48h;

Reference yield:

methanol (67-56-1) + cis-(+/-)-1-(benzyloxycarbonyl)-5-(tert-butoxycarbonylamino)piperidine-3-carboxylic acid → cis-(+/-)-1-benzyl 3-methyl 5-(tert-butoxycarbonylamino)piperidine-1,3-dicarboxylate (1221819-24-4)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In dichloromethane; at 0 ℃; for 48h;

upstream raw materials:

methanol

3,5-Pyridinedicarboxylic acid

dimethyl pyridine-3,5-dicarboxylate

dimethyl piperidine-3,5-dicarboxylate

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