3-CHLORO-4'-METHYL-1,1'-BIPHENYL

Base Information

• Chemical Name: 3-CHLORO-4'-METHYL-1,1'-BIPHENYL
• CAS No.: 19482-08-7
• Molecular Formula: C13H11Cl
• Molecular Weight: 202.683
• Mol file: 19482-08-7.mol

Synonyms:AKOS BAR-1099;3-CHLORO-4'-METHYL-1,1'-BIPHENYL;3-CHLORO-4'-METHYLBIPHENYL

Chemical Property of 3-CHLORO-4'-METHYL-1,1'-BIPHENYL

Chemical Property:

• Melting Point: 33.54 °C
• Boiling Point: 106-112 °C(Press: 0.4 Torr)
• PSA: 0.00000
• Density: 1.107±0.06 g/cm3(Predicted)
• LogP: 4.31540

Purity/Quality:

95% ^*data from raw suppliers

2-Chloro-1-methyl-4-phenylbenzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-CHLORO-4'-METHYL-1,1'-BIPHENYL

There total 7 articles about 3-CHLORO-4'-METHYL-1,1'-BIPHENYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.4%

3-chloro-4-methyliodobenzene (83846-48-4) + sodium carbonate (497-19-8) + phenylboronic acid (98-80-6) → 3-chloro-4-methyl-1,1'-biphenyl (19482-08-7)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; hexane; toluene;

Reference yield: 99.0%

iodobenzene (591-50-4) + B-(3-chloro-4-methylphenyl)boronic acid (175883-63-3) → 3-chloro-4-methyl-1,1'-biphenyl (19482-08-7)

Guidance literature:

With potassium carbonate; In ethanol; at 80 ℃; for 0.5h; Reagent/catalyst; Catalytic behavior;

DOI:10.1055/s-0040-1705989

Reference yield: 87.0%

C13H8ClF3 (933674-79-4) → 3-chloro-4-methyl-1,1'-biphenyl (19482-08-7)

Guidance literature:

With lithium aluminium tetrahydride; titanium tetrachloride; In 1,2-dimethoxyethane; for 1h; Reflux;

DOI:10.1016/j.jfluchem.2013.03.001

upstream raw materials:

3-chloro-p-toluidine

benzene

3-chloro-4-methyliodobenzene

phenylboronic acid

Downstream raw materials:

3-(2-chloro-4-phenylbenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid

5-bromo-3-(2-chloro-4-phenylbenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine

6-bromo-2-[N-(2-chloro-4-phenylbenzyl)acetamido]-3-nitropyridine

6-bromo-2-[N-(2-chloro-4-phenylbenzyl)amino]-3-nitropyridine