5-Bromo-2-chloro-4-fluorobenzoic acid

Base Information

Chemical Name:5-Bromo-2-chloro-4-fluorobenzoic acid
CAS No.:1204219-98-6
Molecular Formula:C₇H₃BrClFO₂
Molecular Weight:253.455
Hs Code.:
European Community (EC) Number:834-815-5
Mol file:1204219-98-6.mol

Synonyms:5-bromo-2-chloro-4-fluorobenzoic acid;1204219-98-6;SCHEMBL1552250;DTJGLOLRNBDUFB-UHFFFAOYSA-N;MFCD24107203;5-bromo-2-chloro-4-fluorobenzoicacid;AKOS020007842;CS-W004398;FT-0722503;EN300-223517;W17792;Z1450923101

Suppliers and Price of 5-Bromo-2-chloro-4-fluorobenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 5-Bromo-2-chloro-4-fluorobenzoic acid

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:251.89890
Heavy Atom Count:12
Complexity:190

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C(=CC(=C1Br)F)Cl)C(=O)O

Technology Process of 5-Bromo-2-chloro-4-fluorobenzoic acid

There total 3 articles about 5-Bromo-2-chloro-4-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143945-65-7
2-amino-4-fluoro-5-bromobenzoic acid

: 1204219-98-6
5-bromo-2-chloro-4-fluorobenzoic acid

Guidance literature:: 2-amino-4-fluoro-5-bromobenzoic acid; With hydrogenchloride; copper(l) chloride; sodium nitrite; In water; at 0 ℃; for 2h;

With hydrogenchloride; copper(l) chloride; In 1,4-dioxane; water; at 0 - 7 ℃;

Reference yield:

: 2252-51-9
2-choro-4-fluorobenzoic acid

: 1204219-98-6
5-bromo-2-chloro-4-fluorobenzoic acid

Guidance literature:: With chlorosulfonic acid; bromine; sulfur; at 70 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.03.052

Reference yield:

: 446-32-2
4-fluoroanthranilic acid

: 1204219-98-6
5-bromo-2-chloro-4-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / -10 °C

2.1: hydrogenchloride; copper(l) chloride; sodium nitrite / water / 2 h / 0 °C

2.2: 0 - 7 °C

With hydrogenchloride; N-Bromosuccinimide; copper(l) chloride; sodium nitrite; In water; N,N-dimethyl-formamide;