(E)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylprop-2-en-1-one

Base Information

• Chemical Name: (E)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylprop-2-en-1-one
• CAS No.: 343609-17-6
• Molecular Formula: C17H14O3
• Molecular Weight: 266.296
• Mol file: 343609-17-6.mol

Synonyms:(E)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylprop-2-en-1-one;(2E)-1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-PHENYLPROP-2-EN-1-ONE

Chemical Property of (E)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylprop-2-en-1-one

Chemical Property:

• Vapor Pressure: 4.32E-08mmHg at 25°C
• Boiling Point: 444.3°C at 760 mmHg
• Flash Point: 214.4°C
• PSA: 35.53000
• Density: 1.217g/cm³
• LogP: 3.35390

Purity/Quality:

99% ^*data from raw suppliers

(E)-1-(2,3-DIHYDROBENZO[B][1,4]DIOXIN-6-YL)-3-PHENYLPROP-2-EN-1-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylprop-2-en-1-one

There total 2 articles about (E)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylprop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 6-iodo-1,4-benzodioxane (57744-67-9) + carbon monoxide (201230-82-2) → (E)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylprop-2-en-1-one (343609-17-6)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; 2-((di-adamantan-1-yl)phosphaneyl)-1-(2,6-diisopropylphenyl)-1H-imidazole; triethylamine; In 1,4-dioxane; at 100 ℃; for 20h; under 3750.38 Torr; Autoclave;

DOI:10.1021/ja1059922

Reference yield: 72.0%

1,4-benzodioxan-6-yl methyl ketone (2879-20-1) + benzaldehyde (100-52-7) → (E)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylprop-2-en-1-one (343609-17-6)

Guidance literature:

With potassium hydroxide; In ethanol; for 10h;

DOI:10.1016/j.bioorg.2019.103335

Reference yield: 87.0%

(E)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-phenylprop-2-en-1-one (343609-17-6) + phenylhydrazine (100-63-0) → 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1,5-diphenyl-4,5-dihydro-1H-pyrazole

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.bmc.2016.05.012

upstream raw materials:

styrene

6-iodo-1,4-benzodioxane

carbon monoxide

1,4-benzodioxan-6-yl methyl ketone

Downstream raw materials:

4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-oxo-2-phenylbutanenitrile