866318-99-2

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-1-[(4-methylphenyl)sulfonyl]-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-1-[(4-methylphenyl)sulfonyl]-;5-fluoro-1-tosyl-1H-pyrrolo [2,3-b]pyridine;5-fluoro-1-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridine
• CAS NO: 866318-99-2
• Molecular Formula: C₁₄H₁₁FN₂O₂S
• Molecular Weight: 290.31
• Mol File: 866318-99-2.mol

Chemical Properties

• Boiling Point: 473.2°C at 760 mmHg
• Flash Point: 240°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 4.02E-09mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-1-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-1-[(4-methylphenyl)sulfonyl]-(866318-99-2)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-1-[(4-methylphenyl)sulfonyl]-(866318-99-2)

Safety Data

• Hazardous Substances Data: 866318-99-2(Hazardous Substances Data)

Usage

Chemical structure

1H-Pyrrolo[2,3-b]pyridine derivative
A compound based on a pyrrolopyridine core structure, which is a fusion of a pyrrole and a pyridine ring.

Substituent

5-fluoro-1-[(4-methylphenyl)sulfonyl]
A functional group attached to the core structure, consisting of a fluorine atom at the 5-position, a sulfonyl group connected to a 4-methylphenyl ring, and an additional carbon atom.

Potential applications

Medicinal chemistry and drug discovery
The compound has diverse biological activities, making it a promising candidate for the development of new drugs and therapies.

Pharmacological property modification

5-fluoro-1-[(4-methylphenyl)sulfonyl] group
The presence of this group allows for the optimization of the compound's pharmacological properties, making it suitable for various therapeutic applications.

Specific uses and effects

Context-dependent and require further research
The exact applications and effects of the compound will depend on the specific context in which it is used and the results of additional research and development.

InChI:InChI=1/C14H11FN2O2S/c1-10-2-4-13(5-3-10)20(18,19)17-7-6-11-8-12(15)9-16-14(11)17/h2-9H,1H3

Upstream product

• 866319-00-8 5-fluoro-1H-pyrrolo[2,3‐b]pyridine 
• 98-59-9 p-toluenesulfonyl chloride 
• 866319-01-9 5-fluoro-3-(2-trimethylsilylethynyl)pyridine-2-amine 
• 936344-74-0 3-ethynyl-5-fluoro-pyridin-2-ylamine 
• 823218-51-5 5-fluoro-3-iodo-pyridin-2-amine 
• 21717-96-4 2-amino-5-fluoropyridine 
• 869557-43-7 3-bromo-5-fluoropyridin-2-amine 

Downstream Products

• 866318-98-1 5-fluoro-2-iodo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 866318-97-0 2-(5,6-dimethoxy-1H-indol-3-yl)-5-fluoro-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1417421-99-8 3-bromo-5-fluoro-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1259279-57-6 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1629869-44-8 pimodivir 

Relevant articles and documents

FORMULATIONS OF AZAINDOLE COMPOUNDS

The present invention relates to pharmaceutical compositions, each comprising a multitude of granules that make up an intragranular phase of the composition, wherein the granules are produced by fluid bed granulation and comprise a HCI salt of Compound (1

METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION

A method of preparing a compound of Formula (I) or a pharmaceutically acceptable salt thereof comprises: (a) reacting Compound (1) or (b) a pharmaceutically acceptable salt thereof with Compound (2) in the presence of water, an organic solvent, a base, an

METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION

A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base

INHIBITORS OF INFLUENZA VIRUSES REPLICATION

Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1)·1/2Η20, Form F of HCl salt of Compound (1)·3Η2

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Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors

Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibit