VUF11207

Base Information

• Chemical Name: VUF11207
• CAS No.: 1378524-41-4
• Molecular Formula: C27H35FN2O4
• Molecular Weight: 470.584
• Mol file: 1378524-41-4.mol

Synonyms:VUF11207;(E)-N-(3-(2-fluorophenyl)-2-Methylallyl)-3,4,5-triMethoxy-N-(2-(1-Methylpyrrolidin-2-yl)ethyl)benzaMide;(E)-N-(3-(2-Fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide trifluoroacetate salt;N-[(2E)-3-(2-Fluorophenyl)-2-methyl-2-propen-1-yl]-3,4,5-trimethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-benzamide trifluoroacetate salt;VUF11207 trifluoroacetate salt;VUF11207 Triflate

Chemical Property of VUF11207

Chemical Property:

• PSA: 51.24000
• LogP: 4.81940
• Storage Temp.: ?20°C
• Solubility.: H2O: soluble5mg/mL, clear (warmed)

Purity/Quality:

99%, ^*data from raw suppliers

VUF11207Triflate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of VUF11207

There total 6 articles about VUF11207 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(E)-3-(2-fluorophenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine (1375800-67-1) + 3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → VUF11207 (1378524-41-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.02.041

Reference yield:

2-Fluorobenzaldehyde (446-52-6) → VUF11207 (1378524-41-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol; water / 0 - 20 °C / Inert atmosphere

2.1: sodium sulfate / dichloromethane / 24 h / 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 1 h / 0 °C / Inert atmosphere

3.2: 0.17 h / 20 °C

3.3: pH > 10

4.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium sulfate; triethylamine; potassium hydroxide; In methanol; ethanol; dichloromethane; water;

DOI:10.1016/j.ejmech.2012.02.041

Reference yield:

Eudesmic acid (118-41-2) → VUF11207 (1378524-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / Reflux

2: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1016/j.ejmech.2012.02.041

upstream raw materials:

(E)-3-(2-fluorophenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine

3,4,5-Trimethoxybenzoyl chloride

(E)-3-(2-fluorophenyl)-2-methylacrylaldehyde

2-Fluorobenzaldehyde

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