ethyl 2-(ethylamino)-2-oxoacetate

Base Information

• Chemical Name: ethyl 2-(ethylamino)-2-oxoacetate
• CAS No.: 20943-60-6
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.158
• Mol file: 20943-60-6.mol

Synonyms:ethyl 2-(ethylamino)-2-oxoacetate

Chemical Property of ethyl 2-(ethylamino)-2-oxoacetate

Chemical Property:

• Boiling Point: 70 °C (2 mmHg)
• PSA: 55.40000
• LogP: 0.07650

Purity/Quality:

99% ^*data from raw suppliers

Ethyl(ethylamino)(oxo)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl N-ethyloxamate is used in the synthesis of Kinase 2 (GRK2) Inhibitors for the treatment of heart failure.

Technology Process of ethyl 2-(ethylamino)-2-oxoacetate

There total 6 articles about ethyl 2-(ethylamino)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.3%

ethylamine (75-04-7,85404-22-4) + oxalic acid diethyl ester (95-92-1) → ethyl 2-(ethylamino)-2-oxoacetate (20943-60-6)

Guidance literature:

Aliquat 336; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

ethanamine hydrochloride (557-66-4) + Ethyl oxalyl chloride (4755-77-5) → ethyl 2-(ethylamino)-2-oxoacetate (20943-60-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

(tert-butoxycarbonyl-ethyl-amino)-oxo-acetic acid ethyl ester (216959-38-5) → ethyl 2-(ethylamino)-2-oxoacetate (20943-60-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4039(98)01855-3

upstream raw materials:

ethylamine

oxalic acid diethyl ester

(tert-butoxycarbonyl-ethyl-amino)-oxo-acetic acid ethyl ester

water

Downstream raw materials:

2-(ethylamino)-2-oxoacetic acid

ethyl 1H-benzo[d]imidazole-2-carboxylate

ethanol

N-ethyl-N'-phenyl-oxalamide

Refernces

• 1、 -. "3. 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application (by machine translation)". Paragraph 0295; 0296; 0297; 0298. . Retrieved 2017/07/01.
• 2、 -. "PYRAZINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES". Page/Page column 28. . Retrieved 2009/10/22.