3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol

Base Information

• Chemical Name: 3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol
• CAS No.: 947144-26-5
• Molecular Formula: C6H3F3N2O4
• Molecular Weight: 224.0942296
• Mol file: 947144-26-5.mol

Synonyms:3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol

Chemical Property of 3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol

Chemical Property:

• Melting Point: 164-165 °C
• Boiling Point: 242.0±40.0 °C(Predicted)
• PKA: 3.62±0.10(Predicted)
• PSA: 99.17000
• Density: 1.77±0.1 g/cm3(Predicted)
• LogP: 1.94300
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol

There total 3 articles about 3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

6-trifluoromethyl-pyridine-2,4-diol (947144-32-3) → 6-trifluoromethyl-3-nitro-2,4-dihydroxypyridine (947144-26-5)

Guidance literature:

With sulfuric acid; nitric acid; In water; at 20 - 50 ℃; for 4.5h;

Reference yield: 70.0%

4-hydroxy-6-(trifluoromethyl)pyridin-2(1H)-one (947144-32-3) → 4-hydroxy-3-nitro-6-trifluoromethyl-1H-pyridin-2-one (947144-26-5)

Guidance literature:

With sulfuric acid; nitric acid; at 20 - 50 ℃; for 5.5h;

DOI:10.1021/op200021a

Reference yield:

4-hydroxy-2-oxo-6-trifluoromethyl-1,2-dihydropyridine-3-carboxylic acid ethyl ester (947144-28-7) → 4-hydroxy-3-nitro-6-trifluoromethyl-1H-pyridin-2-one (947144-26-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / Reflux

2: sulfuric acid; nitric acid / 5.5 h / 20 - 50 °C

With hydrogenchloride; sulfuric acid; nitric acid; In water;

DOI:10.1021/op200021a

upstream raw materials:

6-trifluoromethyl-pyridine-2,4-diol

4-hydroxy-2-oxo-6-trifluoromethyl-1,2-dihydropyridine-3-carboxylic acid ethyl ester

4-hydroxy-6-(trifluoromethyl)pyridin-2(1H)-one

Downstream raw materials:

4-chloro-3-nitro-6-(trifluoromethyl)pyridin-2-ol

benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)amine

benzyl-(2,3-diamino-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

4-amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one

Refernces

• 1、 -. "SPRAY DRIED FORMULATION". Page/Page column 32. . Retrieved 2008/12/05.