Phenacetin-d3

Base Information

• Chemical Name: Phenacetin-d3
• CAS No.: 60902-27-4
• Molecular Formula: C10H10D3NO2
• Molecular Weight: 182.234205334
• Mol file: 60902-27-4.mol

Synonyms:2H-Phenacetin;Phenacetin-C(2)H3;Phenacetin-d3;2,2,2-trideuterio-N-(4-ethoxy-phenyl)-acetamide;

Chemical Property of Phenacetin-d3

Chemical Property:

• PSA: 38.33000
• LogP: 2.11670

Purity/Quality:

98%2H ^*data from raw suppliers

Phenacetin-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Phenacetin-d3 is the labeled analogue of Phenacetin (P294580), an analgesic, antipyretic; component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.

Technology Process of Phenacetin-d3

There total 3 articles about Phenacetin-d3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-ethoxyacetanilide (62-44-2,105931-34-8) → [2H]-Phenacetin (60902-27-4)

Guidance literature:

With sodium borodeuteride; In water-d2; at 150 ℃; for 2h; Inert atmosphere; Microwave irradiation; Sealed tube;

DOI:10.1002/jlcr.3103

Reference yield:

Paracetamol-C(2)H3 (60902-28-5) + ethyl iodide (75-03-6) → [2H]-Phenacetin (60902-27-4)

Guidance literature:

With sodium ethanolate; In ethanol; for 1h; Heating;

DOI:10.1080/004982597239930

Reference yield:

→ [2H]-Phenacetin (60902-27-4)

Guidance literature:

entspr. Amin, 2O;

upstream raw materials:

Paracetamol-C⁽²⁾H₃

ethyl iodide

4-ethoxyacetanilide

Downstream raw materials:

Paracetamol-C⁽²⁾H₃

Refernces

• 1、 Nicholls,Lindon,Caddick,Farrant,Wilson,Nicholson. "NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat". . p. 1175 - 1186. Retrieved 2007/10/03.