CarbaMic acid, (4-borono-3-fluorophenyl)-, C-(phenylMethyl) ester (9CI)

Base Information

Chemical Name:CarbaMic acid, (4-borono-3-fluorophenyl)-, C-(phenylMethyl) ester (9CI)
CAS No.:874290-59-2
Molecular Formula:C14H12BFO4
Molecular Weight:289.071
Hs Code.:2931900090
Mol file:874290-59-2.mol

Synonyms:CarbaMic acid, (4-borono-3-fluorophenyl)-, C-(phenylMethyl) ester (9CI);N-CBZ-4-AMINO-2-FLUOROPHENYLBORONIC ACID;(4-borono-3-fluorophenyl)-, C-(phenylMethyl) ester;4-(benzyloxycarbonyl)-2-fluorophenylboronicacid;(4-Borono-3-fluorophenyl)carbamic acid C-(phenylmethyl) ester;(2-fluoro-4-phenylmethoxycarbonylphenyl)boronic acid;N-(benzyloxycarbonyl)-2-fluorophenylboronic acid

Suppliers and Price of CarbaMic acid, (4-borono-3-fluorophenyl)-, C-(phenylMethyl) ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(4-?Borono-?3-?fluorophenyl)?-carbamicAcidC-?(Phenylmethyl)Ester
100mg
$ 105.00

Crysdot
(4-(((Benzyloxy)carbonyl)amino)-2-fluorophenyl)boronicacid 97%
5g
$ 673.00

ChemScene
Carbamicacid,(4-borono-3-fluorophenyl)-,C-(phenylmethyl)ester9CI
10g
$ 1196.00

ChemScene
Carbamicacid,(4-borono-3-fluorophenyl)-,C-(phenylmethyl)ester9CI
250mg
$ 90.00

ChemScene
Carbamicacid,(4-borono-3-fluorophenyl)-,C-(phenylmethyl)ester9CI
1g
$ 179.00

ChemScene
Carbamicacid,(4-borono-3-fluorophenyl)-,C-(phenylmethyl)ester9CI
5g
$ 716.00

Chemenu
(4-(((Benzyloxy)carbonyl)amino)-2-fluorophenyl)boronicacid 95+%
1g
$ 208.00

Ambeed
(4-(((Benzyloxy)carbonyl)amino)-2-fluorophenyl)boronicacid 97%
1g
$ 581.00

Alichem
(4-(((Benzyloxy)carbonyl)amino)-2-fluorophenyl)boronicacid
1g
$ 177.21

Alichem
(4-(((Benzyloxy)carbonyl)amino)-2-fluorophenyl)boronicacid
5g
$ 751.80

Total 61 raw suppliers

Chemical Property of CarbaMic acid, (4-borono-3-fluorophenyl)-, C-(phenylMethyl) ester (9CI)

Chemical Property:

PKA:8.43±0.58(Predicted)
PSA：66.76000
Density:1.34±0.1 g/cm3(Predicted)
LogP:0.86250
Solubility.:Dichloromethane; Ethanol

Purity/Quality:

99%, ^*data from raw suppliers

(4-?Borono-?3-?fluorophenyl)?-carbamicAcidC-?(Phenylmethyl)Ester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (4-?Borono-?3-?fluorophenyl)?-carbamic Acid C-?(Phenylmethyl) Ester is an intermediate in synthesizing Tedizolid-d3 (T013752), a labelled form of Tedizolid, known as TR-700, which is an oral and i.v administered intracellular antibacterial drug.

Technology Process of CarbaMic acid, (4-borono-3-fluorophenyl)-, C-(phenylMethyl) ester (9CI)

There total 2 articles about CarbaMic acid, (4-borono-3-fluorophenyl)-, C-(phenylMethyl) ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 510729-01-8
(4-bromo-3-fluorophenyl)carbamic acid benzyl ester

: 874290-59-2
2-fluoro-4-(benzyloxycarbonyl)aminophenylboronic acid

Guidance literature:: (4-bromo-3-fluorophenyl)carbamic acid benzyl ester; With isopropylmagnesium bromide; In tetrahydrofuran; at -10 ℃; for 5h;

With n-butyllithium; In tetrahydrofuran; hexane; at -10 ℃; for 1h;

With Trimethyl borate; In tetrahydrofuran; hexane; at -10 ℃; for 2h; Time;

Reference yield: 65.3%

: 5419-55-6
Triisopropyl borate

: 510729-01-8
(4-bromo-3-fluorophenyl)carbamic acid benzyl ester

: 7732-18-5
water

: 874290-59-2
2-fluoro-4-(benzyloxycarbonyl)aminophenylboronic acid

Guidance literature:: Triisopropyl borate; (4-bromo-3-fluorophenyl)carbamic acid benzyl ester; With n-butyllithium; In tetrahydrofuran; at -75 - -70 ℃; Inert atmosphere; Cooling with acetone-dry ice;

water; In tetrahydrofuran; Inert atmosphere;

Reference yield: 87.0%

: 874290-59-2
2-fluoro-4-(benzyloxycarbonyl)aminophenylboronic acid

: 380380-64-3
5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine

: 1220910-89-3
3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester

Guidance literature:: With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; at 70 ℃; for 1h; Inert atmosphere;