tert-Butyl (1-ethynylcyclopropyl)carbaMate

Base Information

• Chemical Name: tert-Butyl (1-ethynylcyclopropyl)carbaMate
• CAS No.: 1268810-09-8
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.235
• Hs Code.: 2916200090
• Mol file: 1268810-09-8.mol

Synonyms:tert-Butyl (1-ethynylcyclopropyl)carbaMate;N-(1-Ethynylcyclopropyl)carbamic acid 1,1-dimethylethyl ester;Carbamic acid, N-(1-ethynylcyclopropyl)-, 1,1-dimethylethyl ester

Chemical Property of tert-Butyl (1-ethynylcyclopropyl)carbaMate

Chemical Property:

• Melting Point: 68-70℃
• Boiling Point: 249.7±10.0 °C(Predicted)
• PKA: 11.37±0.20(Predicted)
• PSA: 38.33000
• Density: 1.05±0.1 g/cm3(Predicted)
• LogP: 2.06780
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

tert-butyl(1-ethynylcyclopropyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl (1-ethynylcyclopropyl)carbaMate

There total 11 articles about tert-Butyl (1-ethynylcyclopropyl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl N-[1-(2-trimethylsilylethynyl)cyclopropyl]carbamate (1268810-08-7) → tert-butyl N-(1-ethynylcyclopropyl)carbamate (1268810-09-8)

Guidance literature:

With potassium fluoride; In water; N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1055/s-0030-1258964

Reference yield: 77.0%

C10H15Cl2NO2 → tert-butyl N-(1-ethynylcyclopropyl)carbamate (1268810-09-8)

Guidance literature:

With methyllithium; In tetrahydrofuran; diethyl ether; at -30 ℃; for 1h; Temperature; Reagent/catalyst; Solvent; Time;

Reference yield: 77.0%

C10H15Cl2NO2 + tert-butyl (1-formylcyclopropyl)carbamate (107259-06-3) + trichloroacetic acid (76-03-9) → tert-butyl N-(1-ethynylcyclopropyl)carbamate (1268810-09-8)

Guidance literature:

tert-butyl (1-formylcyclopropyl)carbamate; trichloroacetic acid; With sodium trichloroacetate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

With acetic anhydride; acetic acid; zinc; In N,N-dimethyl-formamide; at 55 - 60 ℃; for 1h;

C₁₀H₁₅Cl₂NO₂; With methyllithium; In tetrahydrofuran; diethyl ether; at -30 ℃; for 1h;

upstream raw materials:

tert-butyl N-[1-(2-trimethylsilylethynyl)cyclopropyl]carbamate

carbon tetrabromide

tert-butyl (1-formylcyclopropyl)carbamate

trichloroacetic acid

Downstream raw materials:

1-ethynylcyclopropan-1-amine hydrochloric acid

C₂₂H₁₈FN₅O₄S₂

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