tert-butyl (1-((trimethylsilyl)ethynyl)cyclopropyl)carbamate

Base Information

• Chemical Name: tert-butyl (1-((trimethylsilyl)ethynyl)cyclopropyl)carbamate
• CAS No.: 1268810-08-7
• Molecular Formula: C₁₃H₂₃NO₂Si
• Molecular Weight: 253.417
• Mol file: 1268810-08-7.mol

Synonyms:tert-butyl (1-((trimethylsilyl)ethynyl)cyclopropyl)carbamate;Carbamic acid, N-[1-[2-(trimethylsilyl)ethynyl]cyclopropyl]-, 1,1-dimethylethyl ester

Chemical Property of tert-butyl (1-((trimethylsilyl)ethynyl)cyclopropyl)carbamate

Chemical Property:

• Melting Point: 86 °C(Solv: hexane (110-54-3))
• Boiling Point: 303.1±12.0 °C(Predicted)
• PKA: 12.71±0.20(Predicted)
• PSA: 38.33000
• Density: 0.99±0.1 g/cm3(Predicted)
• LogP: 3.31540

Purity/Quality:

99% ^*data from raw suppliers

N-[1-[2-(trimethylsilyl)ethynyl]cyclopropyl]-Carbamicacid1,1-dimethylethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (1-((trimethylsilyl)ethynyl)cyclopropyl)carbamate

There total 4 articles about tert-butyl (1-((trimethylsilyl)ethynyl)cyclopropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-trimethylsilylethynyl)cyclopropanecarboxylic acid (1268810-07-6) + tert-butyl alcohol (75-65-0) → tert-butyl N-[1-(2-trimethylsilylethynyl)cyclopropyl]carbamate (1268810-08-7)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; at 75 ℃; for 16h;

Reference yield:

(2-cyclopropylethynyl)trimethylsilane (81166-84-9) → tert-butyl N-[1-(2-trimethylsilylethynyl)cyclopropyl]carbamate (1268810-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 6 h

1.2: 2 h / -78 °C

2.1: diphenyl phosphoryl azide; triethylamine / 16 h / 75 °C

With n-butyllithium; diphenyl phosphoryl azide; triethylamine; In diethyl ether; hexane;

Reference yield:

Cyclopropylacetylene (6746-94-7) → tert-butyl N-[1-(2-trimethylsilylethynyl)cyclopropyl]carbamate (1268810-08-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methyllithium / 2.17 h / -78 °C

1.2: 3 h / -78 - 20 °C

2.1: n-butyllithium / diethyl ether; hexane / 6 h

2.2: 2 h / -78 °C

3.1: diphenyl phosphoryl azide; triethylamine / 16 h / 75 °C

With n-butyllithium; diphenyl phosphoryl azide; methyllithium; triethylamine; In diethyl ether; hexane;

upstream raw materials:

tert-butyl alcohol

(2-cyclopropylethynyl)trimethylsilane

1-(2-trimethylsilylethynyl)cyclopropanecarboxylic acid

Cyclopropylacetylene

Downstream raw materials:

tert-butyl N-(1-ethynylcyclopropyl)carbamate

1-ethynylcyclopropan-1-amine hydrochloric acid