(6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANOL

Base Information

• Chemical Name: (6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANOL
• CAS No.: 887707-21-3
• Molecular Formula: C7H8ClNO
• Molecular Weight: 157.6
• Hs Code.: 2933399090
• Mol file: 887707-21-3.mol

Synonyms:(6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANOL;2-Chloro-5-hydroxymethyl-3-methylpyridine

Chemical Property of (6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANOL

Chemical Property:

• PSA: 33.12000
• LogP: 1.53570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(6-Chloro-5-methylpyridin-3-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANOL

There total 7 articles about (6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

6-chloro-5-methylpyridine-3-carboxaldehyde (176433-43-5) → (6-chloro-5-methylpyridin-3-yl)methanol (887707-21-3)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2015.11.026

Reference yield: 88.0%

methyl 6-chloro-5-methylnicotinate (65169-42-8) → (6-chloro-5-methylpyridin-3-yl)methanol (887707-21-3)

Guidance literature:

methyl 6-chloro-5-methyl-nicotinate; With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 - 20 ℃; Inert atmosphere;

With rochelle salt; In dichloromethane; toluene;

Reference yield: 12.0%

2-chloro-5-cyano-3-methylpyridine (66909-33-9) → (6-chloro-5-methylpyridin-3-yl)methanol (887707-21-3)

Guidance literature:

2-chloro-5-cyano-3-methylpyridine; With diisobutylaluminium hydride; In toluene; for 4h; cooling;

With sodium tetrahydroborate; In methanol; water; cooling;

DOI:10.1080/00397910500516134

upstream raw materials:

2-chloro-5-cyano-3-methylpyridine

2-Chloro-5-iodo-3-methylpyridine

6-chloro-5-methylpyridine-3-carboxaldehyde

methyl 6-chloro-5-methylnicotinate

Downstream raw materials:

6-chloro-5-methylpyridine-3-carboxaldehyde

C₇H₇BrClN

N-((2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)methyl)-5-(3-fluorophenyl)picolinamide

(6-chloro-5-methylpyridin-3-yl)methanamine hydrochloride

Refernces

• 1、 -. "NOVEL COMPOUNDS FOR MODULATION OF ROR-GAMMA ACTIVITY". Paragraph 00304. . Retrieved 2014/03/22.
• 2、 Kagabu, Shinzo. "Methyl, trifluoromethyl, and methoxycarbonyl - Introduction to the fifth position on the pyridine ring of chloronicotinyl insecticide imidacloprid". . p. 1235 - 1245. Retrieved 2007/10/03.