6-Chloro-5-methylnicotinonitrile

Base Information

Chemical Name:6-Chloro-5-methylnicotinonitrile
CAS No.:66909-33-9
Molecular Formula:C7H5ClN2
Molecular Weight:152.583
Hs Code.:2933399990
European Community (EC) Number:801-046-1
DSSTox Substance ID:DTXSID70470913
Wikidata:Q82299120
Mol file:66909-33-9.mol

Synonyms:66909-33-9;6-Chloro-5-methylnicotinonitrile;2-Chloro-5-cyano-3-picoline;6-chloro-5-methylpyridine-3-carbonitrile;2-Chloro-5-cyano-3-methylpyridine;MFCD09261082;3-Pyridinecarbonitrile, 6-chloro-5-methyl-;SCHEMBL2896194;AMY6232;DTXSID70470913;6-chloro-5-methyl nicotinonitrile;GKSKRJKZUDHSBZ-UHFFFAOYSA-N;AKOS006332376;AB50049;CS-W005726;DS-2177;AC-24301;SY047015;2-CHLORO-3-METHYL-5-CYANOPYRIDINE;A8999;FT-0682281;EN300-178417;J-518599;2-chloro-3-methyl-5-pyridinecarbonitrile, AldrichCPR;Z1198218511

Suppliers and Price of 6-Chloro-5-methylnicotinonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Chloro-5-methylnicotinonitrile
50mg
$ 65.00

TRC
6-Chloro-5-methylnicotinonitrile
10mg
$ 45.00

SynQuest Laboratories
6-Chloro-5-methylnicotinonitrile 98%
5 g
$ 135.00

SynQuest Laboratories
6-Chloro-5-methylnicotinonitrile 98%
250 mg
$ 26.00

Matrix Scientific
6-Chloro-5-methylnicotinonitrile 95%
1g
$ 60.00

Matrix Scientific
6-Chloro-5-methylnicotinonitrile 95%
25g
$ 600.00

Matrix Scientific
6-Chloro-5-methylnicotinonitrile 95%
5g
$ 225.00

Labseeker
6-Chloro-5-methylpyridine-3-carbonitrile 96
20g
$ 1250.00

Frontier Specialty Chemicals
6-Chloro-5-methylpyridine-3-carbonitrile
500mg
$ 100.00

Frontier Specialty Chemicals
6-Chloro-5-methylpyridine-3-carbonitrile
1g
$ 150.00

Total 30 raw suppliers

Chemical Property of 6-Chloro-5-methylnicotinonitrile

Chemical Property:

Melting Point:114-116 °C
Boiling Point:268.0±35.0 °C(Predicted)
PKA:-2.95±0.10(Predicted)
Density:1.26±0.1 g/cm3(Predicted)
Storage Temp.:2-8°C
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:152.0141259
Heavy Atom Count:10
Complexity:160

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-5-methylnicotinonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CN=C1Cl)C#N

Technology Process of 6-Chloro-5-methylnicotinonitrile

There total 5 articles about 6-Chloro-5-methylnicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 59782-89-7
2-Chloro-5-iodo-3-methylpyridine

: 544-92-3
copper(I) cyanide

: 66909-33-9
2-chloro-5-cyano-3-methylpyridine

Guidance literature:: In N,N-dimethyl-formamide; at 160 ℃; for 6.5h;
DOI:10.1080/00397910500516134

Reference yield:

: C₇H₈N₂O₂

: 66909-33-9
2-chloro-5-cyano-3-methylpyridine

: 66909-34-0
2-chloro-5-methylpyridine-3-carbonitrile

Guidance literature:: With trichlorophosphate; at 5 - 100 ℃; for 6.5h;

Reference yield:

: 3222-49-9
5-methylnicotinic acid

: 66909-33-9
2-chloro-5-cyano-3-methylpyridine

: 66909-34-0
2-chloro-5-methylpyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / dichloromethane / 2 h / 20 °C

2: ammonium hydroxide / 1,4-dioxane; tetrahydrofuran / 0.75 h / 0 °C

3: dihydrogen peroxide; acetic acid / 4.5 h / 20 - 80 °C

4: trichlorophosphate / 6.5 h / 5 - 100 °C

With ammonium hydroxide; oxalyl dichloride; dihydrogen peroxide; acetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;