(2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide trifluoroacetate

Base Information

Chemical Name:(2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide trifluoroacetate
CAS No.:1303609-37-1
Molecular Formula:C₂HF₃O₂*C₂₉H₃₄Cl₂FN₃O₃
Molecular Weight:676.536
Hs Code.:

(2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide trifluoroacetate

Synonyms:(2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide trifluoroacetate

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Chemical Property of (2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide trifluoroacetate

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Technology Process of (2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide trifluoroacetate

There total 6 articles about (2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1303607-07-9
(2'R,3S,3'S,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide

: 76-05-1
trifluoroacetic acid

: 1303609-37-1
(2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide trifluoroacetate

Guidance literature:: In dichloromethane;

Reference yield:

: 74444-81-8
5-chloro-1,3-dihydro-2H-inden-2-one

: 1303609-37-1
(2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine / methanol / 3 h / 20 °C

2: toluene / Molecular sieve; Reflux

3: tetrahydrofuran / 48 h / 20 °C

4: ammonium cerium (IV) nitrate / water; acetone; acetonitrile / Cooling with ice

5: dichloromethane

With piperidine; ammonium cerium (IV) nitrate; In tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene; acetonitrile;

Reference yield:

: 897365-76-3
(3E/Z)-6-chloro-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydro-2H-indol-2-one

: 1303609-37-1
(2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / Molecular sieve; Reflux

2: tetrahydrofuran / 48 h / 20 °C

3: ammonium cerium (IV) nitrate / water; acetone; acetonitrile / Cooling with ice

4: dichloromethane

With ammonium cerium (IV) nitrate; In tetrahydrofuran; dichloromethane; water; acetone; toluene; acetonitrile;