3-(5-Methoxy-1H-indol-3-yl)-propionic acid

Base Information

• Chemical Name: 3-(5-Methoxy-1H-indol-3-yl)-propionic acid
• CAS No.: 39547-16-5
• Molecular Formula: C12H13NO3
• Molecular Weight: 219.24
• Hs Code.: 2933990090
• Mol file: 39547-16-5.mol

Synonyms:3-(5-methoxy-indol-3-yl)-propionic acid;3-(5-Methoxy-indol-3-yl)-propionsaeure;3-(5-Methoxy-1H-indol-3-yl)-propionic acid;3-(5-methoxyindol-3-yl)propanoic acid;

Chemical Property of 3-(5-Methoxy-1H-indol-3-yl)-propionic acid

Chemical Property:

• Vapor Pressure: 7.12E-09mmHg at 25°C
• Boiling Point: 449.7°Cat760mmHg
• Flash Point: 225.8°C
• PSA: 62.32000
• Density: 1.29g/cm³
• LogP: 2.19370
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-(5-Methoxy-1H-indol-3-yl)-propionic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(5-Methoxy-1H-indol-3-yl)-propionic acid

There total 13 articles about 3-(5-Methoxy-1H-indol-3-yl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-(1-methanesulfonyl-5-methoxy-2,3-dihydro-1H-indol-3-yl)-propionic acid ethyl ester (474640-47-6) → 3-(5-methoxy-1H-indol-3-yl)propanoic acid (39547-16-5)

Guidance literature:

With sulfuric acid; at 0 ℃; for 0.5h;

DOI:10.1039/b204371h

Reference yield: 46.0%

5-methoxylindole (1006-94-6) + acrylic acid (79-10-7) → 3-(5-methoxy-1H-indol-3-yl)propanoic acid (39547-16-5)

Guidance literature:

With acetic anhydride; acetic acid; at 95 ℃; for 24h;

DOI:10.1002/ejoc.201801842

Reference yield:

ethyl 3-(5-Methoxy-1H-indol-3-yl)propionate (76834-78-1) → 3-(5-methoxy-1H-indol-3-yl)propanoic acid (39547-16-5)

Guidance literature:

With sodium hydroxide; In ethanol; for 1h; Heating;

DOI:10.1021/jm981079+

upstream raw materials:

ethyl 3-(5-Methoxy-1H-indol-3-yl)propionate

3-(1-methanesulfonyl-5-methoxy-2,3-dihydro-1H-indol-3-yl)-propionic acid ethyl ester

N-(4-methoxyphenyl)-N-(prop-2-en-1-yl)methanesulfonamide

4-ethoxythiocarbonylsulfanyl-5-[methanesulfonyl-(4-methoxy-phenyl)-amino]-pentanoic acid ethyl ester

Downstream raw materials:

ethyl 3-(5-Methoxy-1H-indol-3-yl)propionate

5-methoxy-N-acetyl-tryptamine